Zebrafish as a potential biomaterial testing platform for bone tissue engineering application: A special note on chitosan based bioactive materials.

Biomaterials function as an essential aspect of tissue engineering and have a profound impact on cell growth and subsequent tissue regeneration. The development of new biomaterials requires a potential platform to understand the host-biomaterial interaction, which is crucial for successful biomaterial implantation. Biomaterials analyzed in rodent models for in vivo research are cost-effective but tedious, and the practice has many technical difficulties.

Kaempferol-zinc(II) complex synthesis and evaluation of bone formation using zebrafish model.

Flavonoids are known for their wide range of bioactive properties including beneficial effect on bone formation. Their intense metal ion chelating capacity endorsed their nomination as a new biomaterial for biomedical applications. The present study examined the functional role of Kaemferal-Zinc(II) (Kaem-Zn) complex in bone formation, in vitro and in vivo.