Construction of Methotrexate-Loaded BiS Coated with Fe/Mn-Bimetallic Doped ZIF-8 Nanocomposites for Cancer Treatment Through the Synergistic Effects of Photothermal/Chemodynamic/Chemotherapy.

A combination of therapeutic modalities in a single nanostructure is crucial for a successful cancer treatment. Synergistic photothermal therapy (PTT) can enhance the effects of chemodynamic therapy (CDT) and chemotherapy, which could intensify the therapeutic efficacy to induce cancer cell apoptosis. In this study, Fe and Mn on a zeolitic imidazolate framework (ZIF-8) (Fe/Mn-ZIF-8; FMZ) were synthesized through ion deposition.

Facile synthesis of tantalum decorated on iron selenide with nitrogen-doped graphene hybrid for the sensitive detection of trolox in berries: Density functional theory interpretation.

This work presents a hydrothermal method followed by a sonochemical treatment for synthesizing tantalum decorated on iron selenide (Ta/FeSe) integrated with nitrogen-doped graphene (NGR) as a susceptible electrode material for detecting trolox (TRX) in berries samples. The surface morphology, structural characterizations, and electrochemical performances of the synthesized Ta/FeSe/NGR composite were analyzed via spectrophotometric and voltammetry techniques. The GCE modified with Ta/FeSe/NGR demonstrated an impressive linear range of 0.

Dual Z-scheme heterojunction CeSnO/AgPO/V@g-CN for increased photocatalytic degradation of the food additive tartrazine, in the presence of persulfate: Kinetics, toxicity, and density functional theory studies.

This study involved the synthesis of a CeSnO/AgPO/V@g-CN composite through hydrothermal methods, followed by mechanical grinding. The resulting heterojunction exhibited improved catalytic activity under visible light by effectively separating electrons and holes (e/h). The degradation of Tartrazine (TTZ) reached 93.

A CeMgMoO double perovskite decorated on a functionalized carbon nanofiber nanocomposite for quantification of ciprofloxacin in milk and honey samples: Density functional theory interpretation.

In this study, a novel CeMgMoO/CNFs (cerium magnesium molybdite double perovskite decorated on carbon nanofibers) nanocomposite was developed for selective and ultra-sensitive detection of ciprofloxacin (CFX). Physical characterization and analytical techniques were used to explore the morphology, structure, and electrocatalytic characteristics of the CeMgMoO/CNFs nanocomposite. The sensor has a wide linear range (0.

Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment.

Water splitting is promising, especially for energy and environmental applications; however, there are limited studies on the link between water splitting and cancer treatment. Upconversion nanoparticles (UCNPs) can be used to convert near-infrared (NIR) light to ultraviolet (UV) or visible (Vis) light and have great potential for biomedical applications because of their profound penetration ability, theranostic approaches, low self-fluorescence background, reduced damage to biological tissue, and low toxicity. UCNPs with photocatalytic materials can enhance the photocatalytic activities that generate a shorter wavelength to increase the tissue penetration depth in the biological microenvironment under NIR light irradiation.

Gold nanoparticles decorated on MOF derived CuZn hollow porous carbon nanocubes for magnetic resonance imaging guided tumor microenvironment-mediated synergistic chemodynamic and photothermal therapy.

Combining chemodynamic therapy (CDT) with photothermal therapy (PTT) has developed as a promising approach for cancer treatment, as it enhances therapeutic efficiency through redox reactions and external laser induction. In this study, we designed metal organic framework (MOF) -derived CuZn/HPCNC through a carbonization process and decorated them with gold nanoparticles (Au@CuZn/HPCNC). The resulting nanoparticles were employed as a photothermal agent and Fenton catalyst.

A sensitive sandwich-type electrochemical immunosensor using nitrogen-doped graphene/metal-organic framework-derived CuMnCoO and Au/MXene for the detection of breast cancer biomarker.

In terms of cancer-related deaths among women, breast cancer (BC) is the most common. Clinically, human epidermal growth receptor 2 (HER2) is one of the most commonly used diagnostic biomarkers for facilitating BC cell proliferation and malignant growth. In this study, a disposable gold electrode (DGE) modified with gold nanoparticle-decorated TiCT (Au/MXene) was utilized as a sensing platform to immobilize the capturing antibody (Ab/Au/MXene).

2D/2D heterostructure Ni-Fe LDH/black phosphorus nanosheets with AuNP for noxious substance diphenylamine detection in food samples.

In this study, gold nanoparticles decorated on nickel-iron layered double hydroxide with black phosphorus nanosheets (AuNP/Ni-Fe LDH/BPNSs) composite were prepared using a stirring method. Analyte tracing is required for developing viable sensors. The AuNP/Ni-Fe LDH/BPNSs composite exhibited a large specific surface area, high conductivity, high electrocatalytic activity, and rapid electron transfer.

Highly responsive and sensitive non-enzymatic electrochemical sensor for the detection of β-NADH in food, environmental and biological samples using AuNP on polydopamine/titanium carbide composite.

In this study, a polydopamine/titanium carbide adorned with gold nanoparticles (Au@PDA/TiC) composite was prepared by a simple stirring technique and it was used for the dual-technique detection of β-Nicotinamide adenine dinucleotide (NADH). The Au@PDA/TiC-modified glassy carbon electrode (GCE) oxidized NADH at a very low oxidation potential of approximately 0.60 V vs Ag/AgCl in pH = 7.

Polydopamine-Coated Cu-BTC Nanowires for Effective Magnetic Resonance Imaging and Photothermal Therapy.

Herein, we present a one-pot hydrothermal approach for synthesizing metal-organic framework-derived copper (II) benzene-1,3,5-tricarboxylate (Cu-BTC) nanowires (NWs) using dopamine as the reducing agent and precursor for a polydopamine (PDA) surface coating formation. In addition, PDA can act as a PTT agent and enhance NIR absorption, producing photothermal effects on cancer cells. These NWs displayed a photothermal conversion efficiency of 13.

Lanthanum nickelate spheres embedded acid functionalized carbon nanofiber composite: An efficient electrocatalyst for electrochemical detection of food additive vanillin.

Contemporary food marketing is ruined by flavor enhancers rather than emphasizing the nutritional value of food. Vanillin is an overexploited flavor enhancer added to food items, thereby necessitating its detection. In this study, an electrochemical sensor was designed using a modified electrode made up of LaNiO functionalized carbon nanofiber (f-CNF) to effectively detect vanillin in food samples.

A non-enzymatic, biocompatible electrochemical sensor based on N-doped graphene quantum dot-incorporated SnS nanosheets for in situ monitoring of hydrogen peroxide in breast cancer cells.

The current study reports the design and construction of enzyme-free sensor using N-doped graphene quantum dots (N-GQDs)-decorated tin sulfide nanosheets (SnS) for in situ monitoring of HO secreted by human breast cancer cells. N-GQDs nanoparticles having a size of less than 1 nm were incorporated into SnS nanosheets to form an N-GQDs@SnS nanocomposite using a simple hydrothermal approach. The resulting hybrid material was an excellent electrocatalyst for the reduction of HO, owing to the combined properties of highly conductive N-GQDs and SnS nanosheets.

Bimetallic CuZn alloy-embedded hollow porous carbon nanocubes derived from 3D-Cu/ZIF-8 as efficient electrocatalysts for environmental pollutant detection in water bodies.

Excessive use of nitrofurantoin (NFT) and its residues can be harmful to the ecosystem, and to mitigate this, rapid and cost-effective detection of NFT in water bodies is needed. In this regard, we prepared a three-dimensional (3D) copper-zeolitic imidazole framework (Cu/ZIF-8)-derived bimetallic CuZn alloy-embedded hollow porous carbon nanocubes (CuZn/HPCNC) for electrochemical detection of NFT. The resultant material is characterized using suitable spectrophotometry and voltammetry methods.

Irradiation-Induced Synthesis of Ag/ZnO Nanostructures as Surface-Enhanced Raman Scattering Sensors for Sensitive Detection of the Pesticide Acetamiprid.

Detecting pesticides using techniques that involve simple fabrication methods and conducting the detection at very low levels are challenging. Herein, we report the detection of acetamiprid at the quadrillionth level using surface-enhanced Raman scattering (SERS). The SERS chip comprises Ag nanoparticles deposited on a tetrapod structure of ZnO coated onto indium tin oxide glass (denoted as Ag@ZnO-ITO).

A Sandwich-Type Electrochemical Immunosensor for Insulin Detection Based on Au-Adhered Cu Zn Hollow Porous Carbon Nanocubes and AuNP Deposited Nitrogen-Doped Holey Graphene.

Rapid, accurate, and sensitive insulin detection is crucial for managing and treating diabetes. A simple sandwich-type electrochemical immunosensor is engineered using gold nanoparticle (AuNP)-adhered metal-organic framework-derived copper-zinc hollow porous carbon nanocubes (Au@Cu Zn /HPCNC) and AuNP-deposited nitrogen-doped holey graphene (NHG) are used as a dual functional label and sensing platform. The results show that identical morphology and size of Au@Cu Zn /HPCNC enhance the electrocatalytic active sites, conductivity, and surface area to immobilize the detection antibodies (Ab ).

MOF-Derived Cu-BTC Nanowire-Embedded 2D Leaf-like Structured ZIF Composite-Based Aptamer Sensors for Real-Time Insulin Monitoring.

Insulin, which is a hormone produced by the β-cells of the pancreas, regulates the glucose levels in the blood and can transport glucose into cells to produce glycogen or triglycerides. Insulin deficiency can lead to hyperglycemia and diabetes. Therefore, insulin detection is critical in clinical diagnosis.

Preparation of gamma poly-glutamic acid/hydroxyapatite/collagen composite as the 3D-printing scaffold for bone tissue engineering.

Background: All types of movements involve the role of articular cartilage and bones. The presence of cartilage enables bones to move over one another smoothly. However, repetitive microtrauma and ischemia as well as genetic effects can cause an osteochondral lesion.

Biocompatible Electrochemical Sensor Based on Platinum-Nickel Alloy Nanoparticles for In Situ Monitoring of Hydrogen Sulfide in Breast Cancer Cells.

Hydrogen sulfide (HS), an endogenous gasotransmitter, is produced in mammalian systems and is closely associated with pathological and physiological functions. Nevertheless, the complete conversion of HS is still unpredictable owing to the limited number of sensors for accurate and quantitative detection of HS in biological samples. In this study, we constructed a disposable electrochemical sensor based on PtNi alloy nanoparticles (PtNi NPs) for sensitive and specific in situ monitoring of HS released by human breast cancer cells.

Self-templating hydrothermal synthesis of carbon-confined double-shelled Ni/NiO hollow microspheres for diphenylamine detection in fruit samples.

Toxic substances, such as heavy metals, toxins, pesticides, pathogens, and veterinary drug residues in food are hazardous to consumer health. The variety and quantity of food consumption have increased owing to developments in the agricultural and food industries. Food safety has a substantial socioeconomic impact, and an increasing number of consumers have become aware of its importance.

Disposable and cost-effective label-free electrochemical immunosensor for prolactin based on bismuth sulfide nanorods with polypyrrole.

Prolactin (PRL) is produced by the pituitary gland and plays a vital role in the production of milk after a baby is born. PRL levels are normally elevated in pregnant and nursing women, and high levels of PRL in the human body cause hyperprolactinemia, infertility, galactorrhea, infrequent or irregular periods, amenorrhea, breast pain, and loss of libido. Accordingly, herein, a novel label-free immunosensor using a bismuth sulfide/polypyrrole (BiS/PPy)-modified screen-printed electrode (SPE) for the fast and facile detection of the peptide hormone PRL.

Label-free electrochemical immunosensor based on gold nanoparticle/polyethyleneimine/reduced graphene oxide nanocomposites for the ultrasensitive detection of cancer biomarker matrix metalloproteinase-1.

Matrix metalloproteinase-1 (MMP-1) is associated with many types of cancers, including oral, colorectal, and brain cancers. This paper describes the fabrication of an MMP-1 immunosensor based on a gold nanoparticle/polyethyleneimine/reduced graphene oxide (AuNP/PEI/rGO)-modified disposable screen-printed electrode (SPE). A microwave-assisted single-step method was employed for the simultaneous reduction of gold and graphene oxide in a PEI environment to avoid AuNP agglomeration.

Cost-effective single-step synthesis of flower-like cerium-ruthenium-sulfide for the determination of antipsychotic drug trifluoperazine in human urine samples.

Nanostructured binary metal sulfides are considered as a promising electrode material because of their excellent electron transfer and good sensing behavior rather than metal oxides. As a result, the binary metal sulfides were applied in energy and electrochemical sensor applications. Herein, we propose the electrochemical sensor method based on flower-like cerium-ruthenium sulfide nanostructure (Ce-Ru-S NS) for the electrochemical sensing of trifluoperazine (TFPZ).