Publications by authors named "Rajalakshmi Ramamoorthy"
Article Synopsis
- Type C hepatic encephalopathy (Type C HE) is a neurological disorder resulting from chronic liver failure, presenting symptoms like mental confusion and motor difficulties.
- The increase in Alzheimer type II astrocytes (AT2A) is a significant finding linked to Type C HE, though the development of AT2A and its role in cognitive impairments is still unclear.
- Research in rats indicates that elevated oxidative stress, inflammation, and specific signaling pathways contribute to the rise of GMF and AT2A, leading to cognitive and motor deficits, suggesting potential targets for treatment.
The COVID-19 pandemic has been one of the most impactful events in our lifetime, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Multiple SARS-CoV-2 variants were reported globally, and a wide range of symptoms existed. Individuals who contract COVID-19 continue to suffer for a long time, known as long COVID or post-acute sequelae of COVID-19 (PASC).
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- * Research using mouse models infected with a coronavirus (MHV-1) has uncovered significant intestinal changes, resembling conditions like inflammatory bowel disease and celiac disease, which parallel effects seen in humans post SARS-CoV-2 exposure.
- * Treatment with SPIKENET (SPK) shows promise in reducing intestinal damage from MHV-1 infection, highlighting its potential to help restore tissue health and manage inflammatory responses related to long COVID.
The coronavirus disease-19 (COVID-19) pandemic, declared in early 2020, has left an indelible mark on global health, with over 7.0 million deaths and persistent challenges. While the pharmaceutical industry raced to develop vaccines, the emergence of mutant severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) strains continues to pose a significant threat.
View Article and Find Full Text PDFCOVID-19, caused by SARS-CoV-2, has had a significant global impact. While vaccines and treatments have reduced severe cases and deaths, the long-term effects are not yet well understood. Current models used for research, such as non-human primates and transgenic mice, are expensive and require scarce Biosafety Level-3 (BSL-3) laboratories, thereby limiting their practicality.
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- Psoriasis is a chronic skin condition marked by inflammation, thickening, scaling, and redness due to overactive skin cell production, with severity varying based on skin involvement and symptoms.
- Currently, there’s no cure, and common treatments involve conventional drugs which can have severe side effects, prompting exploration of nutraceuticals as alternative management options.
- Research shows that a combination of krill oil, cannabidiol, and myo-inositol may be more effective than other natural treatments for psoriasis, potentially leading to better alternatives to traditional medications.
Signs and symptoms involving multiple organ systems which persist for weeks or months to years after the initial SARS-CoV-2 infection (also known as PASC or long COVID) are common complications of individuals with COVID-19. We recently reported pathophysiological changes in various organs post-acute infection of mice with mouse hepatitis virus-1 (MHV-1, a coronavirus) (7 days) and after long-term post-infection (12 months). One of the organs severely affected in this animal model is the kidney, which correlated well with human studies showing kidney injury post-SARS-CoV-2 infection.
View Article and Find Full Text PDFObjectives: Monkeypox (MPox) is a zoonotic virus in the genus Orthopoxvirus. It is transmitted from animal to human, and between humans. The clinical presentations vary, starting with a prodrome phase to different skin findings and systemic complications.
View Article and Find Full Text PDFPhosphoenolpyruvate carboxylase (PEPC) a cytosolic enzyme of higher plants is also found in bacteria and cyanobacteria. Genetic and biochemical investigations have indicated that there are several isoforms of PEPC belonging to C3; C3/C4 and C4 groups but, the evolution of PEPC in cyanobacteria is not yet understood. The present study opens up an opportunity to understand the isoforms and functions of PEPC in cyanobacteria.
View Article and Find Full Text PDFFour different marine cyanobacterial morphotypes were tested for their efficacy to produce siderophores in Fe minus [Fe(-)], Fe minus Uranium dosed [Fe(-)U(+)], and Fe dosed Uranium dosed [Fe(-)U(+)] media. Of the four organisms tested, Synechococcus elongatus BDU 130911 produced the highest amount of siderophore of 58μgmg(-1) dryweight. The results clearly indicate that uranium induces siderophore production in marine cyanobacteria even in the presence of iron [Fe(-)U(+)] condition.
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