The APOBEC3G gene rs2294367(C>G) variant is associated with HIV-1 infection in Moroccan subjects.

The APOBEC3G gene is one of the most important host factors thathas beenfound previously associated withHIV infection and AIDS progression. The host's susceptibility to viral infectionmay be influenced by any APOBEC3G genetic variation.The main aim of thecurrent study was to investigate the association of three SNPs in the APOBEC3G gene (rs8177832, rs35228531, and rs2294367) respectively, with disease outcomes in Moroccan HIV-1 infected patients.

Prevalence of HBsAg among Moroccan HIV-1 infected patients and APOBEC3G variant frequencies in HIV-1/HBV co-infection.

Introduction: Human immunodeficiency virus (HIV) / hepatitis B virus (HBV) causes higher rates of liver disease compared to infection with just one virus. Co-infection can accelerate the progression to liver fibrosis or hepatocellular carcinoma and disturb the treatment response. APOBEC3G is a host defense factor which interferes with HIV-1 and HBV.

Assessment of two POC technologies for CD4 count in Morocco.

Background: In the era of "test and treat strategy", CD4 testing remains an important tool for monitoring HIV-infected individuals. Since conventional methods of CD4 count measurement are costly and cumbersome, POC CD4 counting technique are more affordable and practical for countries with limited resources. Before introducing such methods in Morocco, we decided to assess their reliability.

[Causes of death among 91 HIV-infected adults in the era of potent antiretroviral therapy].

Objective: To describe the causes of death occurring during the antiretroviral therapy in Casablanca.

Methods: Retrospective study of a cohort of HIV positive patients attending the infectious diseases unit of Casablanca receiving antiretroviral therapy. Files of 91 patients who died were analyzed.

The prevalence of resistance-associated mutations to protease and reverse transcriptase inhibitors in treatment-naïve (HIV1)-infected individuals in Casablanca, Morocco.

Background: The widespread use of antiretroviral agents and the growing occurrence of HIV-1 strains resistant to these drugs have given rise to serious concerns regarding the transmission of resistant viruses to newly infected persons, which may reduce the efficacy of a first-line antiretroviral therapy.

Methodology: RNA was extracted from plasma samples of 98 treatment-naïve individuals with a plasma HIV RNA viral load of at least 1,000 copies/ml. Both protease (pr) and reverse transcriptase (rt) were amplified and sequenced using an automated sequencer.