Management of primary second molar with poor prognosis in patient with bilateral premolar agenesis: A case report with 1-year follow-up.

Bilateral mandibular premolar agenesis is rare, and it is essential to retain the primary teeth until they can be replaced with dental implants. Although internal root resorption and periapical lesions in primary teeth have a poor prognosis, MTA dressing and restoring teeth with SSC impede the progress of internal resorption.

The Effects of Subjective Socioeconomic Status and Social Capital on Self-rated Health and Perceived Quality of Life: A Cross-sectional Survey-based Study in a Minority Group in Iran.

Objectives: The purpose of this study is to examine the impact of subjective socioeconomic status and social capital on self-rated health and quality of life among a minority group in Iran.

Methods: This cross-sectional study involved 800 individuals from a minority group in Iran. The sampling method was clustering, and data collection was conducted using a questionnaire.

Influence of temperament on children's cooperation during dental treatment.

Background: The etiologies of childhood dental fear/dental behavior management problems have been extensively studied, especially the role of children's temperaments. This study aimed to evaluate the effect of temperament and its associated variables on the anxiety and cooperation level of preschool children in a dental clinic.

Materials And Methods: This cross-sectional study involved 103, 4-6-year-old patients (39 boys and 64 girls).

Monitoring the utilization and effectiveness of Iron and Vitamin D supplementations program and its predictive factors in high schools' girls in Qom, Iran.

Background: Iron and Vitamin D3 deficiency is one of the major global health problems in teenagers and adolescent population. This study was aimed to monitor the utilization and predictive factors of Iron and Vitamin D Supplementations Program (IVDSP) in high schools' girls.

Methods: In a cross sectional study, the pattern of Iron and D3 consumption based on IVDSP on 400 high schools' girl in Qom, Iran assesses.

Shaping high-performance wearable robots for human motor and sensory reconstruction and enhancement.

Most wearable robots such as exoskeletons and prostheses can operate with dexterity, while wearers do not perceive them as part of their bodies. In this perspective, we contend that integrating environmental, physiological, and physical information through multi-modal fusion, incorporating human-in-the-loop control, utilizing neuromuscular interface, employing flexible electronics, and acquiring and processing human-robot information with biomechatronic chips, should all be leveraged towards building the next generation of wearable robots. These technologies could improve the embodiment of wearable robots.

The Effect of Three Forms of Local Corticosteroids on Sinonasal Polyposis.

Introduction: Since sinonasal polyposis (SNP) has a high recurrence rate after surgery, various studies have investigated the effect of corticosteroid medications to prevent disease recurrence. The present study was designed to compare the effect of three forms of local corticosteroids on preventing SNP recurrence post-operatively.

Materials And Methods: This double-blind, randomized clinical trial study was conducted on 108 patients with SNP who underwent functional endoscopic sinus surgery (FESS).

A multicenter descriptive analysis of anemia management in hemodialysis patients and its association with quality of life.

Background: Appropriate management of anemia in patients with hemodialysis (HD) involves the administration of iron supplementation and erythropoietin-stimulating agents (ESAs), in addition to monitoring the response. This study aimed to evaluate the treatment of anemia in patients with HD and describe the factors associated with it and its effect on health-related quality of life (HRQOL).

Methods: The study was cross-sectional in design.

Synthesis and characterization of gentamicin loaded ZSM-5 scaffold: Cytocompatibility and antibacterial activity.

Porous structure, biocompatibility and biodegradability, large surface area, and drug-loading ability are some remarkable properties of zeolite structure, making it a great possible option for bone tissue engineering. Herein, we evaluated the potential application of the ZSM-5 scaffold encapsulated GEN with high porosity structure and significant antibacterial properties. The space holder process has been employed as a new fabrication method with interconnected pores and suitable mechanical properties.

Photodynamic therapy with zinc phthalocyanine enhances the anti-cancer effect of tamoxifen in breast cancer cell line: Promising combination treatment against triple-negative breast cancer?

Photodynamic therapy (PDT) is a light-based anti-neoplastic therapeutic approach. Growing evidence indicates that combining conventional anti-cancer therapies with PDT can be a promising approach to treat malignancies. Herein, we aimed to investigate anti-cancer effects of the combination treatment of zinc phthalocyanine (ZnPc)-PDT with tamoxifen (TA) on MDA-MB-231 cells (as a triple-negative breast cancer (TNBC) cell line).

Layered scaffolds in periodontal regeneration.

Periodontitis is a common inflammatory disease in dentistry that may lead to tooth loss and aesthetic problems. Periodontal tissue has a sophisticated architecture including four sections of alveolar bone, cementum, gingiva, and periodontal ligament fiber; all these four can be damaged during periodontitis. Thus, for whole periodontal regeneration, it is important to form both hard and soft tissue structures simultaneously on the tooth root surface without forming junctional epithelium and ankylosis.

Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase.

The sirtuin enzymes are a family of lysine deacylases that regulate gene transcription and metabolism. Sirtuin 5 (SIRT5) hydrolyzes malonyl, succinyl, and glutaryl ϵ-N-carboxyacyllysine posttranslational modifications and has recently emerged as a vulnerability in certain cancers. However, chemical probes to illuminate its potential as a pharmacological target have been lacking.

Antibacterial Activity and Cell Responses of Vancomycin-Loaded Alginate Coating on ZSM-5 Scaffold for Bone Tissue Engineering Applications.

Despite the significant advancement in bone tissue engineering, it is still challenging to find a desired scaffold with suitable mechanical and biological properties, efficient bone formation in the defect area, and antibacterial resistivity. In this study, the zeolite (ZSM-5) scaffold was developed using the space holder method, and a novel vancomycin-loaded alginate coating was developed on it to promote their characteristics. Our results demonstrated the importance of alginate coating on the microstructure, mechanical, and cellular properties of the ZSM-5 scaffold.

Carbon-chalcogen bond formation initiated by [Al(NON)(E)] anions containing Al-E{16} (E{16} = S, Se) multiple bonds.

Multiply-bonded main group metal compounds are of interest as a new class of reactive species able to activate and functionalize a wide range of substrates. The aluminium sulfido compound K[Al(NON)(S)] (NON = [O(SiMeNDipp)], Dipp = 2,6-PrCH), completing the series of [Al(NON)(E)] anions containing Al-E{16} multiple bonds (E{16} = O, S, Se, Te), was accessed desulfurisation of K[Al(NON)(S)] using triphenylphosphane. The crystal structure showed a tetrameric aggregate joined by multiple K⋯S and K⋯π(arene) interactions that were disrupted by the addition of 2.

DFT calculations bring insight to internal alkyne-to-vinylidene transformations at rhodium PNP- and PONOP-pincer complexes.

Density Functional Theory (DFT) has been used to investigate the alkyne-to-vinylidene isomerisation reaction mediated by [Rh(PXNXP)] complexes (X = CH: 2,6-bis(di--butylphosphinomethyl)pyridine (PNP) and X = O: 2,6-bis(di--butylphosphinito)pyridine (PONOP)) for terminal alkynes HC[triple bond, length as m-dash]CR, where R = Bu and Ar' (3,5- BuCH). Calculations suggest the reaction mechanism proceeds the slippage of π-bound alkyne at the Rh centre into a Rh-alkyne σ complex followed by an indirect 1,2-H shift to give the Rh-vinylidene species. NBO (Natural Bond Orbital) analysis of the transition states corresponding to the latter indirect 1,2-H shift step indicates that the migrating hydrogen atom exhibits protic character and hence, the basicity of the H-accepting centre (C) is controlled by the substituents at that same atom and can tune the 1,2-H shift transition state.

Developing of specific monoclonal recombinant antibody fused to alkaline phosphatase (AP) for one-step detection of fig mosaic virus.

Present study was performed to develop a fusion recombinant monoclonal antibody for one-step and accurate detection of FMV with a specific single-chain variable fragment (scFv) fused to alkaline phosphatase (AP) named as scFv(FMV-NP)-AP. The gene encoding-specific scFv recombinant antibody binding to nucleocapsid protein of (FMV-NP) was fused to upstream of AP gene and integrated in pET26b bacterial expression vector. As vector contain signal peptide, the expressed protein is secreted into periplasmic compartment.

The Efficacy of (Teltonal) in Patients with Knee Osteoarthritis: A Randomized Active-Controlled Clinical Trial.

Purpose: The high prevalence of knee osteoarthritis (KOA) is a major cause of disability among elders. NSAIDs are recommended to reduce KOA patients' symptoms, but their adverse side effects limit their consumption. In this study, we evaluated the effectiveness of compared to a routine NSAID (meloxicam) on pain reduction and functional improvement of KOA patients.

Bonding and Reactivity of a Pair of Neutral and Cationic Heterobimetallic RuZn Complexes.

A combined experimental and computational study of the structure and reactivity of two [RuZnMe] complexes, neutral [Ru(PPh)(PhPCH)(ZnMe)] () and cationic [Ru(PPh)(PhPCH)(ZnMe)][BAr] ([BAr] = [B{3,5-(CF)CH}]) (), is presented. Structural and computational analyses indicate these complexes are best formulated as containing discrete ZnMe ligands in which direct Ru-Zn bonding is complemented by weaker Zn···Zn interactions. The latter are stronger in , and both complexes exhibit an additional Zn···C interaction with a cyclometalated phosphine ligand, this being stronger in .

Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase.

Sirtuin 3 (SIRT3) is the major protein lysine deacetylase in the mitochondria. This hydrolase regulates a wide range of metabolically involved enzymes and has been considered as a potential drug target in certain cancers. Investigation of pharmacological intervention has been challenging due to a lack of potent and selective inhibitors of SIRT3.

Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration.

Sirtuin 2 (SIRT2) is a protein deacylase enzyme that removes acetyl groups and longer chain acyl groups from post-translationally modified lysine residues. It affects diverse biological functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and cancer. Therefore, access to well-characterized and robust tool compounds is essential for the continued investigation of the complex functions of this enzyme.

Seven-Membered Cyclic Potassium Diamidoalumanyls.

The seven-membered cyclic potassium alumanyl species, [{SiN }AlK] [{SiN }={CH SiMe N(Mes)} ; Mes=2,4,6-Me C H ], which adopts a dimeric structure supported by flanking K-aryl interactions, has been isolated either by direct reduction of the iodide precursor, [{SiN }AlI], or in a stepwise manner via the intermediate dialumane, [{SiN }Al] . Although the intermediate dialumane has not been observed by reduction of a Dipp-substituted analogue (Dipp=2,6-i-Pr C H ), partial oxidation of the potassium alumanyl species, [{SiN }AlK] , where {SiN }={CH SiMe N(Dipp)} , provided the extremely encumbered dialumane [{SiN }Al] . [{SiN }AlK] reacts with toluene by reductive activation of a methyl C(sp )-H bond to provide the benzyl hydridoaluminate, [{SiN }AlH(CH Ph)]K, and as a nucleophile with BPh and RN=C=NR (R=i-Pr, Cy) to yield the respective Al-B- and Al-C-bonded potassium aluminaborate and alumina-amidinate products.

Knowledge and attitude of Palestinian women to contraceptives: a cross-sectional study.

Background: Contraceptives have documented efficiency, but outcomes are highly dependent on women's understanding of how they should be used. We assessed the knowledge and attitudes of married Palestinian women about contraceptives and understanding of use of the available methods and side-effects.

Methods: This cross-sectional study involved married Palestinian women of childbearing age (18-50 years), and was done between Jan 20, 2017, and Jan, 1, 2018.

[Ni(NHC) ] as a Scaffold for Structurally Characterized trans [H-Ni-PR ] and trans [R P-Ni-PR ] Complexes.

The addition of PPh H, PPhMeH, PPhH , P(para-Tol)H , PMesH and PH to the two-coordinate Ni N-heterocyclic carbene species [Ni(NHC) ] (NHC=IiPr , IMe , IEt Me ) affords a series of mononuclear, terminal phosphido nickel complexes. Structural characterisation of nine of these compounds shows that they have unusual trans [H-Ni-PR ] or novel trans [R P-Ni-PR ] geometries. The bis-phosphido complexes are more accessible when smaller NHCs (IMe >IEt Me >IiPr ) and phosphines are employed.

SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA.

We discovered that the survival and growth of many primary acute myeloid leukemia (AML) samples and cell lines, but not normal CD34+ cells, are dependent on SIRT5, a lysine deacylase implicated in regulating multiple metabolic pathways. Dependence on SIRT5 is genotype-agnostic and extends to RAS- and p53-mutated AML. Results were comparable between SIRT5 knockdown and SIRT5 inhibition using NRD167, a potent and selective SIRT5 inhibitor.