Publications by authors named "Raja Y Zaghlol"

Article Synopsis
  • The study aimed to explore how reducing medication doses for diabetes affects the risk of glycemic issues in individuals fasting during Ramaḍān.
  • Conducted in Amman, Jordan, 687 type 2 diabetes patients were randomly assigned to either low or regular medication doses; 678 completed the trial to evaluate incidences of hypoglycemia and hyperglycemia.
  • Results showed that those on lower doses had significantly fewer hypoglycemic episodes while hyperglycemia rates were similar between the two groups, highlighting the safety of dosage reduction during fasting.
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Tumor-targeted therapies such as trastuzumab have led to significant improvements in survival of human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, these therapies have also been associated with significant left ventricular dysfunction. The incidence of trastuzumab-induced heart failure has decreased significantly since the initial reports, in large part due to improved screening, closer monitoring for early changes in left ventricular function, and a significant decrease in the concurrent administration of anthracyclines.

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Anthracyclines are the cornerstone of therapy for a wide range of solid and hematologic malignancies; however, their use is limited by the risk of chemotherapy-induced cardiotoxicity leading to cardiomyopathy and heart failure. The incidence of cardiotoxicity in the literature depends on the definition being used, anthracycline dose, duration of follow-up, and surveillance methods used to identify cardiac injury. The reported risk of clinical heart failure has been around 2% to 4% with low-dose anthracycline regimens, whereas the incidence of cardiac injury defined by an abnormal increase in cardiac biomarkers has been reported as high as 35%.

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Background: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease that may lead to hypothyroidism due to progressive destruction of the thyroid. The etiology of HT is unclear. However, it is associated with multiple genetic predispositions.

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