Text Mining and Machine Learning Protocol for Extracting Human-Related Protein Phosphorylation Information from PubMed.

In the modern health care research, protein phosphorylation has gained an enormous attention from the researchers across the globe and requires automated approaches to process a huge volume of data on proteins and their modifications at the cellular level. The data generated at the cellular level is unique as well as arbitrary, and an accumulation of massive volume of information is inevitable. Biological research has revealed that a huge array of cellular communication aided by protein phosphorylation and other similar mechanisms imply different and diverse meanings.

Text Mining Protocol to Retrieve Significant Drug-Gene Interactions from PubMed Abstracts.

Genes and proteins form the basis of all cellular processes and ensure a smooth functioning of the human system. The diseases caused in humans can be either genetic in nature or may be caused due to external factors. Genetic diseases are mainly the result of any anomaly in gene/protein structure or function.

Neuromorphic Architecture Accelerated Automated Seizure Detection in Multi-Channel Scalp EEG.

Epileptic focal seizures can be localized in the brain using tracer injections during or immediately after the incidence of a seizure. A real-time automated seizure detection system with minimal latency can help time the injection properly to find the seizure origin accurately. Reliable real-time seizure detection systems have not been clinically reported yet.

Role of 18F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography Imaging in the Prediction of Prognosis in Patients With Indolent Lymphoma: Prospective Study.

Background: The role of fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in indolent lymphoma has been minimally studied.

Objective: This study aims to assess the value of FDG-PET/CT in predicting the prognosis of indolent lymphoma.

Methods: We prospectively recruited 42 patients with indolent lymphoma.

Management and treatment recommendations for World Health Organization Grade III and IV gliomas.

The treatment recommendations provided in this manuscript are intended to serve as a knowledge base for clinicians and health personals involved in treating patients with high-grade malignant glioma. In newly diagnosed patients, complete resection or biopsy is required for histological characterization of the tumor, which in turn is essential to decide the treatment strategy. In patients with good or borderline performance score, radiotherapy (RT), and chemotherapy are the preferred management.

Computed tomography virtual bronchoscopy: normal variants, pitfalls, and spectrum of common and rare pathology.

A broad spectrum of pathologies that involve the laryngotracheobronchial airway and imaging plays a crucial role in evaluating these abnormalities. Computed tomography with virtual bronchoscopy has been found to be very helpful in defining the location, extent, and nature of these lesions, and is increasingly being used even in patients with contraindications for fiberoptic bronchoscopy and laryngoscopy. Ionizing radiation, associated with virtual bronchoscopy, can be minimized by using low-dose multidetector computed tomography and hybrid iterative reconstruction techniques.

Normative MDCT cross-sectional data estimation of superior vena cava and innominate vein in growing children using age as a predictor.

This retrospective study aimed to determine the superior vena cava (SVC) and left innominate vein (INV) normative cross-sectional area in children noninvasively using age as a predictor and also to compare the correlation of the area measured with the diameter on multidetector computed tomography (MDCT). Analysis of the SVC-INV cross-sectional area was performed for 73 consecutive patients. The cross-sectional area of the SVC-INV was manually estimated.

Image-guided biopsy: what the interventional radiologist needs to know about PET/CT.

Positron emission tomography (PET)/computed tomography (CT) with fluorine 18 fluorodeoxyglucose (FDG) is increasingly used in evaluation of oncology patients. Because PET/CT can demonstrate malignancy before morphologic changes are evident, application of PET/CT information to image-guided biopsy can facilitate early histologic diagnosis and staging. However, because FDG uptake is not specific to cancer, PET/CT findings may raise questions about whether uptake in a lesion is an indication for biopsy.

FDG PET scan in a primitive neuroectodermal tumor.

Primitive peripheral neuroectodermal tumor (PNET) is a rare tumor that often arises in soft tissue. Magnetic resonance imaging is a good diagnostic tool that can establish the extent of disease. The utility of positron emission tomography (PET) using F-18-fluoro-2-deoxy-D-glucose (FDG) in the diagnostic work-up and staging of PNET has not been well established.

Automated 3-dimensional elastic registration of whole-body PET and CT from separate or combined scanners.

Unlabelled: Registration and fusion of whole-body functional PET and anatomic CT is significant for accurate differentiation of viable tumors from benign masses, radiotherapy planning and monitoring treatment response, and cancer staging. Whole-body PET and CT acquired on separate scanners are misregistered because of differences in patient positions and orientations, couch shapes, and breathing protocols. Although a combined PET/CT scanner removes many of these misalignments, breathing-related nonrigid mismatches still persist.

Radionuclide evaluation of pleural-peritoneal shunt before pleurodesis.

Objectives: Talc pleurodesis can be offered to patients with hepatic hydrothorax. The authors wanted to determine their patient's eligibility for talc pleurodesis by excluding a pleural-peritoneal shunt.

Materials And Methods: The authors measured the size of the talc particles and matched them with the radionuclide particle size.

Mutual information-based multimodality registration of cardiac ultrasound and SPECT images: a preliminary investigation.

Background: Ultrasound (US) and single photon emission computed tomography (SPECT) are the two most commonly prescribed procedures for diagnosing coronary artery disease (CAD). We have demonstrated the feasibility of multimodality registration of two-dimensional (2D) and three-dimensional (3D) cardiac US images with cardiac SPECT images with an aim to simultaneously present the complementary anatomical and perfusion information from the two modalities. We have also tested the clinicians' assessment of the clinical adequacy of the registered images.

Neocortical temporal FDG-PET hypometabolism correlates with temporal lobe atrophy in hippocampal sclerosis associated with microscopic cortical dysplasia.

Purpose: Medically intractable temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS), with or without cortical dysplasia (CD), is associated with atrophy of the hippocampal formation and regional fluorodeoxyglucose positron-emission tomography (FDG-PET) hypometabolism. The relation between areas of functional and structural abnormalities is not well understood. We investigate the relation between FDG-PET metabolism and temporal lobe (TL) and hippocampal atrophy in patients with histologically proven isolated HS and HS associated with CD.

Ictal urinary urge: further evidence for lateralization to the nondominant hemisphere.

Purpose: To determine the lateralizing value of ictal urinary urgency.

Methods: A retrospective database search was performed for patients with ictal urinary urgency admitted to the Epilepsy Monitoring Unit at the Cleveland Clinic between 1994 and 2001.

Results: Six patients were identified; intracarotid amytal test demonstrated left hemispheric speech dominance in five cases.

Laparoscopic anatrophic nephrolithotomy: feasibility study in a chronic porcine model.

PURPOSE Anatrophic nephrolithotomy performed via open surgery involves incising the renal parenchyma along an avascular plane to remove a large, complex renal stone. We determined the feasibility of performing laparoscopic anatrophic nephrolithotomy in a survival porcine model. Furthermore, we present a novel technique of creating a staghorn calculus in the porcine model.

Percutaneous endopyeloplasty: a novel technique.

Background And Purpose: Despite a 10% to 15% failure rate, endopyelotomy remains the treatment of choice for most patients with ureteropelvic junction (UPJ) obstruction. We present a novel technique of percutaneous endopyeloplasty, wherein a precise, full-thickness approximation of a standard longitudinal endopyelotomy incision is performed in a horizontal Heineke-Mikulicz fashion through the conventional solitary percutaneous tract via a nephroscope. We assess the feasibility and efficacy of percutaneous endopyeloplasty in a chronic porcine bilateral UPJ obstruction model and compare outcome data with those#10; of conventional endopyelotomy and laparoscopic pyeloplasty.