Case series of scleral patch grafts during COVID-19 pandemic.

Scleral graft is done for clinical conditions as scleral melt post pterygium surgery, immune or infection related scleral melt, for covering the tubes of Ahmed glaucoma valve implant, for covering the orbital implants post enucleation, etc. A review of literature revealed the use of sclera for corneal perforations in the past, but became obsolete after the cornea being used for patch grafts. Now in this COVID-19 time, due to scarcity of corneal tissue, this technique of scleral patch grafts can be considered as an alternative to corneal patch grafts, which serves well the tectonic/therapeutic purpose and helps salvage the eye.

Sepiapterin alleviates impaired gastric nNOS function in spontaneous diabetic female rodents through NRF2 mRNA turnover and miRNA biogenesis pathway.

An impaired nitrergic system and altered redox signaling contribute to gastric dysmotility in diabetics. Our earlier studies show that NF-E2-related factor 2 (NRF2) and phase II antioxidant enzymes play a vital role in gastric neuronal nitric oxide synthase (nNOS) function. This study aims to investigate whether supplementation of sepiapterin (SEP), a precursor for tetrahydrobiopterin (BH) (a cofactor of NOS) via the salvage pathway, restores altered nitrergic systems and redox balance in spontaneous diabetic (DB) female rats.

Development of an experimental set-up for low-temperature spectroscopic studies of matrix-isolated molecules and molecular ices using synchrotron radiation.

An experimental set-up for studying photophysics and photochemistry of molecules in an inert gas medium (matrix-isolated) and in the ice phase at low temperatures has been developed and commissioned at the Photophysics beamline, Indus-1 synchrotron radiation source. This end-station uses an in-house-developed closed-cycle cryostat for achieving cryo-temperatures (∼10 K). Synchrotron radiation from the Photophysics beamline is used as the source of UV-VUV photons and the system is equipped with a Fourier transform infrared spectrometer for characterization of the molecular species formed at low temperature.

Spectroscopy of N,N-dimethylformamide in the VUV and IR regions: Experimental and computational studies.

The electronic absorption spectrum of N,N-dimethylformamide (DMF) is studied in the 45 000-80 000 cm (5.6-9.9 eV) region using synchrotron radiation.

Vacuum ultraviolet photoabsorption of prime ice analogues of Pluto and Charon.

Here we present the first Vacuum UltraViolet (VUV) photoabsorption spectra of ice analogues of Pluto and Charon ice mixtures. For Pluto the ice analogue is an icy mixture containing nitrogen (N), carbon monoxide (CO), methane (CH) and water (HO) prepared with a 100:1:1:3 ratio, respectively. Photoabsorption of icy mixtures with and without HO were recorded and no significant changes in the spectra due to presence of HO were observed.

Electronic spectroscopy of ethyl bromide probed by VUV photoabsorption and quantum chemical calculations.

The electronically excited states of ethyl bromide and its deuterated isotopologue (CHBr and CDBr) are studied using synchrotron radiation based photoabsorption spectroscopy in the wavenumber region 50 000-86 000 cm. A detailed spectral analysis supported by quantum chemical calculations is presented. A complex Rydberg series structure comprising of nsa, npa, npe, nda and nde series, converging to each of the two spin-orbit split components of the first ionization potential (E and E) is observed for both the isotopologues.

Qualitative observation of reversible phase change in astrochemical ethanethiol ices using infrared spectroscopy.

Here we report the first evidence for a reversible phase change in an ethanethiol ice prepared under astrochemical conditions. InfraRed (IR) spectroscopy was used to monitor the morphology of the ice using the SH stretching vibration, a characteristic vibration of thiol molecules. The deposited sample was able to switch between amorphous and crystalline phases repeatedly under temperature cycles between 10K and 130K with subsequent loss of molecules in every phase change.

Proteogenomics of Candida tropicalis--An Opportunistic Pathogen with Importance for Global Health.

The frequency of Candida infections is currently rising, and thus adversely impacting global health. The situation is exacerbated by azole resistance developed by fungal pathogens. Candida tropicalis is an opportunistic pathogen that causes candidiasis, for example, in immune-compromised individuals, cancer patients, and those who undergo organ transplantation.

Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance.

We present a case of a 47-year-old man with 4 months history of conical growth on the prepuce with a progressive increase in size. The patient had been treated for seminoma a decade ago. Histopathology of the growth showed features of angiokeratoma.

Bullous Fixed Drug Eruption Probably Induced by Paracetamol.

We report a case of a 42-year-old male who presented with second episode of bullous eruptions after ingestion of paracetamol. There were no systemic complaints. The temporal correlation with the drug, history of a similar episode and the quick improvement led us to a diagnosis of bullous fixed drug due to paracetamol.

Nanofluid heat transfer under mixed convection flow in a tube for solar thermal energy applications.

The solar flat plate collector operating under different convective modes has low efficiency for energy conversion. The energy absorbed by the working fluid in the collector system and its heat transfer characteristics vary with solar insolation and mass flow rate. The performance of the system is improved by reducing the losses from the collector.

Corrole-BODIPY Dyads: Synthesis, Structure, and Electrochemical and Photophysical Properties.

A free-base and its Cu(III) derivative of bichromophoric meso-β linked corrole-BODIPY dyad were synthesized and structurally characterized by single crystal X-ray diffraction (XRD). Both corrole and BODIPY fragments maintained respective ground state electronic isolation despite their connection through a single bond due to a tilted orientation as observed by XRD. This was further supported by UV-vis and cyclic voltammetric studies.

A selective fluoride sensor and a digital processor with "Write-Read-Erase-Read" behaviour.

An easy-to-synthesize Schiff base as a selective and colorimetric fluoride sensor via modulation of intramolecular charge transfer (ICT) has been demonstrated. A typical dual-ion binding property along with its distinct reversibility has been explored for YES, NOR and INH logic functions and a potential "Write-Read-Erase-Read" mimic.

Ozone and carbon trioxide synthesis by low energy ion implantation onto solid carbon dioxide and implications to astrochemistry.

Ion implantation experiments were carried out on amorphous (30 K) and crystalline (80 K) solid CO2 using both reactive (D(+), H(+)) and non-reactive (He(+)) ions, simulating different irradiation environments on satellite and dust grain surfaces. Such ion irradiation synthesized several new species in the ice including ozone (O3), carbon trioxide (CO3), and carbon monoxide (CO) the main dissociation product of carbon dioxide. The yield of these products was found to be strongly dependent upon the ion used for irradiation and the sample temperature.

Infrared spectrum of formamide in the solid phase.

Infrared spectra of solid formamide are reported as a function of temperature. Solid formamide samples were prepared at 30 K and then annealed to higher temperatures (300 K) with infrared transmission spectra being recorded over the entire temperature range. The NH(2) vibrations of the formamide molecule were found to be particularly very sensitive to temperature change.

Note: characterization of CaF2/acetone bandpass photon detector with Kr filter gas.

A modified design of a CaF(2)/acetone bandpass photon detector that uses Kr as a filter gas to tune the energy resolution is presented. Our design combines two standard single window detector tubes to build the Kr filter gas chamber. Synchrotron radiation has been used to determine the energy resolution of the detector, as a function of Kr pressure.

Lung resistance protein and multidrug resistance protein in non-small cell lung cancer and their clinical significance.

This study examined lung resistance protein (LRP) and multidrug resistance protein (MRP) in lung tumour tissue from 92 patients with non-small cell lung cancer (NSCLC) and normal lung tissue from 20 patients with benign lung tumours. The rates for LRP- and MRP-positive tumours among the NSCLC cases were 54% and 59%, respectively, and their combined positive rate was 45%. These rates were significantly higher than in normal lung tissue.

Leaching of ions from materials used in alternative restorative technique under neutral and acidic conditions: a comparative evaluation.

This study was undertaken to gain an insight into the interaction of conventional glass ionomers (GC Fuji II, GC Fuji IX GP and Chem Flex restorative materials) commonly used in Alternative Restorative Technique (ART) with aqueous solutions in terms of water sorption, solution buffering and ion release. Both immature and mature specimens of all materials evaluated, showed a substantial increase in mass, pH and release of Na, Ca, Sr, Al, Si, P and F following immersion in deionized water lactic acid (pH 2.7) and lactic acid (pH 5.

NetPath: a public resource of curated signal transduction pathways.

We have developed NetPath as a resource of curated human signaling pathways. As an initial step, NetPath provides detailed maps of a number of immune signaling pathways, which include approximately 1,600 reactions annotated from the literature and more than 2,800 instances of transcriptionally regulated genes - all linked to over 5,500 published articles. We anticipate NetPath to become a consolidated resource for human signaling pathways that should enable systems biology approaches.

Development and validation of a stability indicating LC method for the assay and related substances determination of exemestane, an aromatase inhibitor.

A selective stability indicating HPLC method was developed and validated for quantification of impurities (process related and degradants) and assay determination of Exemestane. Stability indicating power of the method was established by forced degradation experiments and mass balance study. The chromatographic separation was achieved with Hypersil BDS-C-18 using gradient elution.

VUV electronic state spectroscopy of 1,1-difluoroethene and difluorochloromethane by high resolution synchrotron radiation.

High resolution VUV photoabsorption spectra of 1,1-difluoroethene (C(2)H(2)F(2)) and difluorochloromethane (CF(2)HCl) are reported in the wavelength range 115-200 nm (10.8-6.2 eV).

Single step isolation of sildenafil from commercially available Viagra tablets.

Sildenafil, the active ingredient in Viagra, has been purified from commercially available tablets. The purification, using Sephadex G25 chromatography under conditions of low ionic strength, is simple and inexpensive. Sildenafil purified according to this protocol has been characterized with respect to its IC50 for PDE5, its ultraviolet absorption profile, and by collision-induced dissociation fingerprinting, positive ion nanospray, and MALDI mass spectrometry.