A hybrid Transformer-LSTM model apply to glucose prediction.

The global prevalence of diabetes is escalating, with estimates indicating that over 536.6 million individuals were afflicted by 2021, accounting for approximately 10.5% of the world's population.

Checkpoint Inhibitor-Related Capillary Leak Syndrome (CLS).

Immune checkpoint inhibitors (ICIs) are now being widely used for the treatment of various malignancies, but they have a distinctive set of side effects due to the overactivation of the immune system, which is important to recognize. Capillary leak syndrome (CLS) is a rare but potentially life-threatening side effect of ICIs that causes a significant increase in the permeability of capillaries, leading to the leakage of plasma-containing proteins from these small vessels. This condition results in several clinical features, including edema, hypotension, hypoalbuminemia, and hemoconcentration.

Pathological mutations promote proteolysis of mitochondrial tRNA-specific 2-thiouridylase 1 (MTU1) via mitochondrial caseinolytic peptidase (CLPP).

MTU1 controls intramitochondrial protein synthesis by catalyzing the 2-thiouridine modification of mitochondrial transfer RNAs (mt-tRNAs). Missense mutations in the MTU1 gene are associated with life-threatening reversible infantile hepatic failure. However, the molecular pathogenesis is not well understood.

Mesenchymal stem cells derived from bone marrow and adipose tissue for repairing acute sciatic nerve injury in a rabbit model.

Peripheral nerve injury is one of the common disabling clinical conditions and around 50% of the cases end up in permanent impairment. Due to the lack of effective treatment options regenerative medicine employing stem cells is being evaluated. The presented study evaluated and compared regeneration potential of mesenchymal stem cells (MSCs) derived from bone marrow (BM) and adipose tissue (AD) in acute rabbit sciatic nerve injury (axonotmesis) model.

Blockchain and COVID-19 pandemic: applications and challenges.

The year 2020 has witnessed the emergence of coronavirus (COVID-19) that has rapidly spread and adversely affected the global economy, health, and human lives. The COVID-19 pandemic has exposed the limitations of existing healthcare systems regarding their inadequacy to timely and efficiently handle public health emergencies. A large portion of today's healthcare systems are centralized and fall short in providing necessary information security and privacy, data immutability, transparency, and traceability features to detect fraud related to COVID-19 vaccination certification, and anti-body testing.

Bioefficacy of an Oil-Emulsion Formulation of Entomopathogenic Fungus, against Adult Red Palm Weevil, .

The red palm weevil (RPW), , poses a severe threat to agro-industrial crops, particularly major cultivated palm species. Infestations result in economic losses due to reduced fruit quality and yield. The entomopathogenic fungus, , has shown promise as a potential biocontrol agent against the RPW.

Secondary Hypertension Due to Underlying Takayasu Arteritis.

A young female patient in her early 20s of Hispanic descent presented to the hospital with new-onset chest pain and uncontrolled hypertension. She was found to have blood pressure in the 200s/100s. She was evaluated for causes of secondary hypertension and underwent computed tomography angiography (CTA) of her abdomen to rule out fibromuscular dysplasia, which showed abnormal thickening of lower thoracic and abdominal aorta extending into both renal arteries causing stenosis.

Cytoplasmic Antineutrophil Cytoplasmic Antibodies (C-ANCA) Vasculitis: An Uncommon Complication After Stem Cell Transplantation.

Granulomatosis with polyangiitis (GPA) is a rare, autoimmune, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis of uncertain etiology. The incidence of autoimmune complications following stem cell transplant is around 2-5%, with autoimmune cytopenia reported most frequently. We present a case of a 65-year-old male patient who presented to the hospital with productive cough, dyspnea, and fever for five months after haploidentical stem cell transplantation.

Urinothorax: A Rare Cause of Pleural Effusion.

Urinothorax is a rare cause of pleural effusion, which is seen in patients with obstructive uropathy, blunt trauma, or ureteric injury during abdominal surgical procedures. Clinical symptoms may include dyspnea, chest pain, cough, fever, abdominal pain, and decreased urine output. Diagnosis is made by thoracentesis, which would reveal fluid with a urine-like odor, and pleural fluid analysis, which would show if fluid is transudative in nature with a pH lower than 7.

Blockchain for deep learning: review and open challenges.

Deep learning has gained huge traction in recent years because of its potential to make informed decisions. A large portion of today's deep learning systems are based on centralized servers and fall short in providing operational transparency, traceability, reliability, security, and trusted data provenance features. Also, training deep learning models by utilizing centralized data is vulnerable to the single point of failure problem.

Blockchain-Based Forward Supply Chain and Waste Management for COVID-19 Medical Equipment and Supplies.

The year 2020 has witnessed unprecedented levels of demand for COVID-19 medical equipment and supplies. However, most of today's systems, methods, and technologies leveraged for handling the forward supply chain of COVID-19 medical equipment and the waste that results from them after usage are inefficient. They fall short in providing traceability, reliability, operational transparency, security, and trust features.

Pathophysiology of streptokinase-induced hypotension in acute myocardial infarction: a systematic review of clinical evidence.

Introduction: Despite the common occurrence of streptokinase-induced hypotension among patients with acute myocardial infarction, the underlying pathophysiology remains obscure and poorly understood. Our study aimed to pool clinical evidence on the potential mechanism of streptokinase-induced hypotension through a systematic review of the literature.

Material And Methods: We conducted literature search from Medline, Scopus and Web of Science on clinical studies related to streptokinase-induced hypotension.

Bioconjugate synthesis, phytochemical analysis, and optical activity of NiFeO nanoparticles for the removal of ciprofloxacin and Congo red from water.

In this paper, Jr.NiFeO nanoparticles (NPs) were synthesized first time using the leaves extract of Juglans regia via a straightforward process. The physio and phytochemical analysis of plant confirm the presence of macromolecules which function as bio-reductant and stabilize the nanoparticles.

The role of blockchain technology in telehealth and telemedicine.

Objective: Telehealth and telemedicine systems aim to deliver remote healthcare services to mitigate the spread of COVID-9. Also, they can help to manage scarce healthcare resources to control the massive burden of COVID-19 patients in hospitals. However, a large portion of today's telehealth and telemedicine systems are centralized and fall short of providing necessary information security and privacy, operational transparency, health records immutability, and traceability to detect frauds related to patients' insurance claims and physician credentials.

Biomechanical properties of a novel locking compression plate to stabilize oblique tibial osteotomies in buffaloes.

Objective: Quantitation of mechanical properties of a novel locking compression plate (LCP) for bovine tibia.

Study Design: Prospective in vitro study.

Sample Population: Adult Murrah buffalo (250-350 kg) tibiae.

Measuring the shape of microbends in optical fibers.

We report on the distributed shape measurement of small deformations produced along the length of an optical fiber. The fiber contains multiple waveguiding cores, each inscribed with weak continuous Bragg gratings. The distributed Bragg-reflectivity data for the fiber cores, obtained from the optical backscatter reflectometry, are used to estimate the local curvature and the position of the fiber.

Polarization-maintained propagation of a 2200 μm effective-area higher-order-mode in a bent optical fiber.

We report on the excitation and polarization preserved propagation of a very large effective-area (A ∼ 2240 μm) higher-order-mode in an optical fiber. A laser signal operating in the 1 μm wavelength region is transported in a Bessel-like LP mode over a 10 m long section of the polarization-maintaining higher-order-mode fiber. We observe that the light propagates through the fiber with >10 dB polarization-extinction-ratio as the fiber is coiled into circular loops of 40 cm diameter.

Calciphylaxis due to metastatic well-differentiated neuroendocrine carcinoma.

A 70-year-old man with history of metastatic well-differentiated neuroendocrine carcinoma was presented to the hospital with a painful left lower extremity ulcer which started around 3 months prior to presentation. He was treated with antibiotics for cellulitis on multiple occasions with no improvement in his symptoms. On initial laboratory evaluation, he was found to have acute kidney injury and a normal calcium level.

Cavernous Sinus Thrombosis due to Chronic Bacterial Sinusitis.

The cavernous sinus is the most frequent dural sinus to become infected and thrombosed. Septic cavernous sinus thrombosis has become rare since the advent of antibiotics. We herein present a case of septic cavernous sinus thrombosis caused by chronic bacterial sinusitis.

Animal mesenchymal stem cell research in cartilage regenerative medicine - a review.

Healing of articular cartilage is a major clinical challenge as it also lacks a direct vasculature and nerves, and carries a limited number of resident chondrocytes that do not proliferate easily. Damaged articular cartilages are usually replaced by fibrocartilages, which are mechanically and structurally weaker and less resilient. Regenerative medicine involving stem cells is considered to have a definitive potential to overcome the limitations associated with the currently available surgical methods of cartilage repair.