Publications by authors named "Raj Kishori Lal"

Herbal medicines are popular natural medicines that have been used for decades. The use of alternative medicines continues to expand rapidly across the world. The World Health Organization suggests that quality assessment of natural medicines is essential for any therapeutic or health care applications, as their therapeutic potential varies between different geographic origins, plant species, and varieties.

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Unlabelled: CIM-Saumya is an improved, methyl chavicol rich variety of (Family-Lamiaceae), developed by Council of Scientific and Industrial Research-Central Institute of Medicinal and Aromatic Plants. This plant possesses analgesic, anti-ulcerogenic, anti-inflammatory, anti-oxidant, cardiac stimulant, Central Nervous System depressant, hepatoprotective and immunomodulator activities due to the presence of various phytoconstituents. Among them rosmarinic acid, caffeic acid and ferulic acid are the three major phenolic compounds responsible for its therapeutic utility.

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The mosquito repellent Nepetalactone rich Nepeta cataria L. (catmint) plant has a variety of therapeutic and industrial potential. Reports on the genetic diversity of N.

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Article Synopsis
  • - The study investigates the benefits of a new herbal formulation (HACBF) on reducing oxidative stress and improving cognitive function, which are critical in combating aging and neurodegenerative diseases.
  • - HACBF was shown to lower aging biomarkers and enhance the activity of antioxidant enzymes, with effects comparable to common Alzheimer’s and Parkinson’s medications like donepezil and L-Dopa.
  • - Molecular analysis indicated that HACBF positively influences neurotransmitter levels and gene expression related to healthy aging, suggesting it could be a valuable resource for cognitive enhancement, particularly during the ongoing COVID-19 pandemic.
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To understand the altered developmental changes and associated gene expression in inter-genomic combinations, a study was planned in two diverse yet closely related species of targeting their hybrid F1 and amphidiploids. The existing developmental variations between F1 and amphidiploids was analyzed through phenotypical and anatomical assessments. The absence of 8330 transcripts of F1 in amphidiploids and the exclusive presence of two transcripts related to WNK lysine-deficient protein kinase and geranylgeranyl transferase type-2 subunit beta 1-like proteins in amphidiploids provided a set of genes to compare the suppressed and activated functions between F1 and amphidiploids.

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Article Synopsis
  • The research aimed to enhance flower size, yield, and pyrethrins content in pyrethrum through genetic improvement, specifically using gamma radiation to create mutants.
  • Pyrethrum seeds were irradiated with varying doses of gamma rays, leading to the development of 20 mutant families from 90 total, with promising candidates being tested over four years for yield performance.
  • Two mutants, 7 (40 Gy-5) and 10 (40GY-8), showed significant improvements in both dry flower yield and pyrethrins content, making them strong candidates for future cultivation.
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microRNAs are small non-coding RNA molecule that plays an important role in metabolism. Chrysopogon zizanioides (L.) Roberty is an important aromatic plant used in perfumery industries, soil, water conservation, and agricultural practices.

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To develop elite mutants in chamomile ( [L.] Rauschert) for increasing the quantity and quality of essential oil rich in acetylenic compound (2,8)-matricaria acid methyl ester by applying -rays irradiation. Molecular and chemical analysis was performed for ithe dentification/differentiation of mutant genotype.

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Transcriptome analysis and biochemical characterization of the putative l-3,4-dihydroxyphenylalanine (l-DOPA) pathway in Mucuna pruriens (L.) DC have been performed. Spatio-temporal quantification of the putative l-DOPA biosynthetic pathway genes and its correlation with respective metabolites was established.

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Purpose: To develop elite genotypes in Mucuna pruriens (L.) DC with high L-DOPA (L-3, 4 dihydroxyphenylalanine) yields, with non-itching characteristics and better adaptability by applying γ-irradiation. Molecular and chemical analysis was performed for screening based on specific characteristics desired for developing suitable genotypes.

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Background: Ocimum sanctum L. (O. tenuiflorum) family-Lamiaceae is an important component of Indian tradition of medicine as well as culture around the world, and hence is known as "Holy basil" in India.

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Article Synopsis
  • The study focuses on the genus Ocimum, known for its medicinal and aromatic properties, by performing transcriptome sequencing on two key species, O. sanctum and O. basilicum, to understand their genomic resources.
  • The sequencing resulted in over 69,000 transcripts for O. sanctum and over 130,000 for O. basilicum, with a strong amount of those being related to secondary metabolism pathways, particularly in terpenoid and phenylpropanoid biosynthesis.
  • This research provides a foundational comparative analysis of Ocimum species, offering insights that could aid in gene characterization and the development of plants with desirable essential oil profiles.
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Hydroxylase/acetyltransferase elicitors and cyclooxygenase inhibitor along with various precursors from primary shikimate and secoiridoid pools have been fortified to vincamine less hairy root clone of Vinca minor to determine the regulatory factors associated with vincamine biosynthesis. Growth kinetic studies revealed that acetyltransferase elicitor acetic anhydride and terpenoid precursor loganin significantly reduce the growth either supplemented alone or in combination (GI = 140.6 ± 18.

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