Visible light photoredox-catalyzed arylative cyclization to access benzimidazo[2,1-]isoquinolin-6(5)-ones.

A photoredox-catalyzed arylative radical cascade involving -acryloyl-2-arylbenzoimidazoles and diaryliodonium triflates leading to the formation of a broad array of pharmaceutically important arylated-benzimidazo[2,1-]isoquinolin-6(5)-ones is described. Importantly, the synthesized benzimidazoisoquinolinones are amenable for further synthetic manipulation and allowed efficient access to benzimidazo-fused polycyclic heterocycles.

Visible Light Photoredox-Catalyzed Direct C-H Arylation of Quinoxalin-2(1)-ones with Diaryliodonium Salts.

A photoredox-catalyzed direct arylation of quinoxalin-2-(1)-ones using diaryliodonium triflates as the convenient, stable, and cheap aryl source is described. A broad variety of quinoxalin-2-(1)-ones are shown to react with structurally and electronically diverse diaryliodonium triflates, allowing efficient access to a wide variety of pharmaceutically important 3-arylquinoxalin-2-(1)-ones. The presented method is attractive with regard to operational simplicity, mild conditions, broad scope, scalability, and high functional group tolerance.