Publications by authors named "Raj Bapuji"

Article Synopsis
  • Regulatory applications for cell therapies face more objections than traditional drugs, primarily due to inadequacies in preclinical evidence like study design and animal model selection, causing delays in approvals.
  • A scoping review of 1215 documents from major regulatory agencies identified 182 relevant papers, highlighting the critical role of understanding the mechanism of action in preclinical studies.
  • While most guidelines stressed using clinically relevant preclinical models and intervention parameters, there were fewer specific recommendations on disease models and proper study designs like randomization and blinding.
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Introduction: Teaching point-of-care ultrasonography (PoCUS) to medical students is resource intensive. Peer-assisted learning, where the teacher can be a medical student, may be a feasible alternative to expert-led learning. The objective of this systematic review and meta-analysis was to compare the PoCUS performance assessments of medical students receiving peer-assisted vs expert-led learning.

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Introduction: Cytochrome P450s (CYPs) are a superfamily of monooxygenases with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it metabolizes endogenous substrates such as N-3/N-6 polyunsaturated fatty acids (PUFA) to produce lipid mediators involved in homeostasis and cardioprotective responses. Expanding our knowledge of the role CYP2J2 has within the heart is important for understanding its impact on cardiac health and disease.

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Use of 24-hour ambulatory blood pressure monitoring is strongly endorsed by contemporary hypertension guidelines. The objective of this study was to assess patient perceptions of ambulatory blood pressure testing, tolerability, accessibility, and expense. A convenience sample of 50, consenting patients undergoing ambulatory blood pressure monitoring at the University of Alberta Hypertension Clinic in Edmonton, Canada was studied.

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