Publications by authors named "Raiza Sales Pereira Bizerra"
Bacillus subtilis spores have received growing attention regarding potential biotechnological applications, including the use as probiotics and in vaccine formulations. B. subtilis spores have also been shown to behave as particulate vaccine adjuvants, promoting the increase of antibody responses after co-administration with antigens either admixed or adsorbed on the spore surface.
View Article and Find Full Text PDFA genetic and pathologic study of a DENV2 clinical isolate capable of inducing encephalitis and hematological disturbances in immunocompetent mice.
Jaime Henrique Amorim Raíza Sales Pereira Bizerra Rúbens Prince dos Santos Alves Maria Elisabete Sbrogio-Almeida José Eduardo Levi
PLoS One
February 2013
Dengue virus (DENV) is the causative agent of dengue fever (DF), a mosquito-borne illness endemic to tropical and subtropical regions. There is currently no effective drug or vaccine formulation for the prevention of DF and its more severe forms, i.e.
View Article and Find Full Text PDFArticle Synopsis
- The dengue virus non-structural 1 (NS1) protein is important for evading immune defenses and can be targeted for vaccine development due to its correlation with protective immunity.
- In a study, BALB/c mice were vaccinated with a recombinant NS1 protein paired with various adjuvants, including LT(G33D), which resulted in a significant immune response and 50% protective immunity against dengue virus type 2 (DENV2).
- Mice vaccinated with LT(G33D) showed stronger antibody responses along with fewer side effects compared to those vaccinated with Freund’s adjuvant, indicating a safer and more effective vaccine formulation.