Publications by authors named "Raiza Raianne Luz Rodrigues"

The continuous increase in bacterial resistance requires the study and development of new biocompatible antibacterial materials. Galactomannan gum was extracted from endosperms of Dimorphandra gardneriana seeds, modified through quaternization reactions (with NaOH/CHPTAC), and evaluated for antimicrobial activity. Four quaternized derivatives were obtained (QG1-QG4).

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Background: Leishmaniasis is responsible for approximately 65,000 annual deaths. Various Leishmania species are the predominant cause of visceral, cutaneous, or mucocutaneous leishmaniasis, affecting millions worldwide. The lack of a vaccine, emergence of resistance, and undesirable side effects caused by antileishmanial medications have prompted researchers to look for novel therapeutic approaches to treat this disease.

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Leishmaniasis is a group of infectious diseases transmitted to humans during vector bites and caused by protozoans of the genus . Conventional therapies face challenges due to their serious side effects, prompting research into new anti-leishmania agents. In this context, we investigated the effectiveness of morolic acid, a pentacyclic triterpene, on promastigotes and amastigotes.

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Epiisopiloturine (EPI) is a compound found in jaborandi leaves with antiparasitic activity, which can be enhanced when incorporated into nanoparticles (NP). Cashew Gum (CG), modified by carboxymethylation, is used to produce polymeric nanomaterials with biological activity. In this study, we investigated the antimicrobial potential of carboxymethylated CG (CCG) NP containing EPI (NPCCGE) and without the alkaloid (NPCCG) against bacteria and parasites of the genus Leishmania.

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Leishmaniasis, presenting the highest number of cases worldwide is one of the most serious Neglected Tropical Diseases (NTDs). Clinical manifestations are intrinsically related to the host's immune response making immunomodulatory substances the target of numerous studies on antileishmanial activity. The currently available drugs used for treatment present various problems including high toxicity, low efficacy, and associated drug resistance.

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Article Synopsis
  • Tree-exuded gums, particularly cashew gum from Anacardium trees in Brazil, are valuable natural polymers used in food and pharmaceuticals, known for their useful properties like hydro-solubility.
  • Researchers aimed to enhance the properties of cashew gum by chemically modifying it through an amine reaction, which was verified using various analytical techniques, including NMR and infrared spectroscopy.
  • The modification improved the gum's molar mass and thermal stability without inducing cytotoxic effects on macrophage cells at concentrations lower than 50.0 mg/L.
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Leishmaniasis is a group of infectious-parasitic diseases with high mortality rates, and endemic in many regions of the globe. The currently available drugs present serious problems such as high toxicity, costs, and the emergence of drug resistance. This has stimulated research into new antileishmania drugs based on natural products and their derivatives.

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Article Synopsis
  • Leishmaniasis is a serious infectious disease impacting millions globally, with current treatments like pentavalent antimonials posing toxicity and resistance issues.
  • The study highlights the promising effects of Eugenia uniflora L. essential oil, particularly the component curzerene, which shows significant antileishmanial activity while sparing healthy cells.
  • Curzerene not only effectively inhibits various forms of the Leishmania parasite but also enhances immune responses in infected macrophages, making it a strong candidate for future research and potential treatment options.
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Background: Leishmaniasis is a parasitosis with a wide incidence in developing countries. The drugs which are indicated for the treatment of this infection usually are able to promote high toxicity.

Purpose: A combination of limonene and carvacrol, monoterpenes present in plants with antiparasitic activity may constitute an alternative for the treatment of these diseases.

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Leishmaniasis is considered as one of the most Neglected Tropical Diseases (NTDs) in the world, caused by protozoan parasites of the genus Leishmania. Treatment of leishmaniasis by chemotherapy remains a challenge because of limited efficacy, toxic side effects, and drug resistance. The search for new therapeutic agents from natural sources has been a constant for the treatment of diseases such as leishmaniasis.

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Leishmaniasis is caused by several protozoan species of Leishmania, and being endemically present in 98 countries around the world, it is also a severe public-health problem. The available antileishmanial drugs are toxic and yet present risks of recurrent infection. Efforts to find new, effective, and safe oral agents for the treatment of leishmaniasis are continuing throughout the world.

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Background: Chemoinformatics has several applications in the field of drug design, helping to identify new compounds against a range of ailments. Among these are Leishmaniasis, effective treatments for which are currently limited.

Objective: To construct new indole 2-aminothiophene molecules using computational tools and to test their effectiveness against Leishmania amazonensis (sp.

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Article Synopsis
  • * The study investigates the effects of methyl gallate (MG) on Leishmania (L.) amazonensis in vitro, testing its ability to inhibit both the promastigote and amastigote forms of the parasite while assessing its safety in macrophage cells.
  • * Results show that MG is highly effective against the parasites with lower cytotoxicity compared to standard drugs, and it works by enhancing immune responses and cellular activities in macrophages, suggesting it could be an innovative treatment option for leishmaniasis.
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