The safe use of Doliocarpus dentatus in the gestational period: Absence of changes in maternal reproductive performance, embryo-fetal development and DNA integrity.

Ethnopharmacological Relevance: Doliocarpus dentatus (Dilleniaceae) is commonly used in Brazil for the treatment of inflammatory process pain and urinary retention. Previous studies of our group have demonstrated the anti-inflammatory and antimycobacterial action of the ethanolic extract of Doliocarpus dentatus (EEDd) as well as the safety of its use.

Aim Of The Study: we investigated the effects of EEDd on reproductive performance, fetal development and DNA integrity in pregnant female Swiss mice.

Anti-inflammatory, antimycobacterial and genotoxic evaluation of Doliocarpus dentatus.

Ethnopharmacological Relevance: Doliocarpus dentatus is a medicinal plant widely used in Mato Grosso do Sul State for removing the swelling pain caused by the inflammation process and for treating urine retention.

Aim Of The Study: The genotoxic aspects and the anti-inflammatory and antimycobacterial activity of the ethanolic extract obtained from the leaves of D. dentatus (EEDd) were investigated.