Differentiation Between Pellucid-Like Keratoconus and Pellucid Marginal Degeneration Using Swept-Source Optical Coherence Tomography.

Purpose: The distinction between pellucid-like keratoconus (PLK) and pellucid marginal corneal degeneration (PMD) based on tomographic examinations is difficult. In this study, corneal tomographic and biomechanical parameters, after classifying PMD and PLK using swept-source optical coherence tomography, were analyzed.

Methods: Diagnoses of PLK and PMD were made using SS-OCT imaging, two groups were formed: PLK (n = 30) and PMD (n = 10).

Evaluation of indices for the assessment and classification of keratoconus based on optical coherence tomography and Scheimpflug technology.

Purpose: To compare the parameters and indices of a novel swept-source optical coherence tomography device (SS-OCT, ANTERION) with those of a rotating Scheimpflug camera (RSC)-based tomograph (Pentacam) in normal and keratoconic (KC) eyes.

Methods: This prospective, monocentric, cross-sectional study included individuals with unoperated normal and KC eyes, selecting one eye per subject. Ectasia-specific parameters analysed with the SS-OCT were difference in mean keratometry (K) in the inferior and superior meridians, maximum keratometry value (K), elevation of the posterior surface at the thinnest point, screening corneal objective risk of ectasia (SCORE) and thinnest point thickness.

The Increase in Corneal Stiffness After Accelerated Corneal Cross-Linking in Progressive Keratoconus Using Different Methods of Epithelial Debridement.

Purpose: The purpose of this study was to investigate corneal stiffening after epithelium-off accelerated corneal cross-linking (CXL; 9 mW/cm²) in progressive keratoconus (KC) with different methods of epithelial debridement.

Methods: This was a retrospective, interventional, and non-randomized study. In group 1, the epithelium was removed using a hockey knife (N = 45).

Crosslinking with UV-A and riboflavin in progressive keratoconus: From laboratory to clinical practice - Developments over 25 years.

Changes in the biomechanical and biochemical properties of the human cornea play an important role in the pathogenesis of ectatic diseases. A number of conditions in primarily acquired (keratoconus or pellucid marginal degeneration) or secondarily induced (iatrogenic keratectasia after refractive laser surgeries) ectatic disorders lead to decreased biomechanical stability. Corneal collagen cross-linking (CXL) represents a technique to slow or even halt the progression of ectatic pathologies.

Corneal cross-linking for treatment of keratoconus relapse in post-keratoplasty eyes.

Purpose: Keratoconus relapse after penetrating keratoplasty is a rare condition that may result in severe visual deterioration and corneal graft thinning. Therefore, treatment to stabilize the cornea should be considered. The purpose of this study was to evaluate the safety and efficacy of Corneal Cross-Linking (CXL) in eyes with relapse of keratoconus after penetrating keratoplasty for keratoconus.

Analysis of riboflavin/ultraviolet a corneal cross-linking by molecular spectroscopy.

Corneal cross-linking (CXL) with riboflavin and ultraviolet A light is a therapeutic procedure to restore the mechanical stability of corneal tissue. The treatment method is applied to pathological tissue, such as keratoconus and induces the formation of new cross-links. At present, the molecular mechanisms of induced cross-linking are still not known exactly.

Corneal Crosslinking With Riboflavin and UVA Light in Progressive Keratoconus: Fifteen-Year Results.

Purpose: To analyze the 15-year results of corneal crosslinking (CXL) in progressive keratoconus.

Design: Retrospective follow-up analysis of interventional study patients.

Methods: This study included keratoconic eyes with progressive disease treated from 2001 to 2006 at the Department of Ophthalmology, Carl Gustav Carus University Hospital, TU Dresden, Germany.

Evaluation of Biomechanical Changes After Accelerated Cross-Linking in Progressive Keratoconus: A Prospective Follow-Up Study.

Purpose: The aim of this study was to analyze the biomechanical effect of accelerated corneal cross-linking (9*10) in progressive keratoconus (KC) in comparison to untreated fellow eyes using Scheimpflug-based tonometry (Corvis ST, CVS).

Methods: Forty-three eyes of 43 patients with KC showed progressive KC and were treated using accelerated corneal cross-linking. Twenty-five untreated fellow eyes were used as the control group.

Repeatability of corneal deformation response parameters by dynamic ultra-high-speed Scheimpflug imaging before and after corneal crosslinking.

Purpose: To evaluate the repeatability of deformation corneal response (DCR) parameters before and after corneal crosslinking (CXL) compared with their untreated fellow eyes (uFEs).

Setting: University Hospital Carl Gustav Carus, Dresden, Germany; IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Design: Multicenter, interventional reliability analysis.

Evaluation of Corneal Biomechanical Indices in Distinguishing Between Normal, Very Asymmetric, and Bilateral Keratoconic Eyes.

Purpose: To evaluate the ability of biomechanical indices provided by the Ocular Response Analyzer (ORA; Reichert Ophthalmic Instruments) and dynamic Scheimpflug analyzer (Corvis ST; Oculus Optikgeräte GmbH) to distinguish between normal eyes and eyes with very asymmetric ectasia (VAE) and mild and moderate keratoconus.

Methods: This prospective, observational, and monocentric study included normal eyes (defined as keratoconus percentage index < 60, Belin/Ambrósio total deviation value [BAD-D] < 1.6, inferior-superior keratometry [I-S value] < 1.

Comparison of corneal tomography using a novel swept-source optical coherence tomographer and rotating Scheimpflug system in normal and keratoconus eyes: repeatability and agreement analysis.

Background: To determine the repeatability and agreement using corneal tomography of a swept-source optical coherence tomographer (SS-OCT) compared to a rotating Scheimpflug camera (RSC) in normal eyes and keratoconus (KC) eyes.

Methods: This prospective repeatability analysis was performed at the Department of Ophthalmology of University Hospital Carl Gustav Carus, Dresden, Germany. Forty-three normal and 57 KC eyes were enrolled in the study.

Statistical Evaluation of Correlated Measurement Data in Longitudinal Setting Based on Bilateral Corneal Cross-Linking.

Purpose: In ophthalmology, data from both eyes of a person are frequently included in the statistical evaluation. This violates the requirement of data independence for classical statistical tests (e.g.

Corneal Biomechanics Differences Between Chinese and Caucasian Healthy Subjects.

Purpose: The aim of this study was to evaluate the difference between Caucasian and Chinese healthy subjects with regards to Corvis ST dynamic corneal response parameters (DCRs).

Methods: Two thousand eight hundred and eighty-nine healthy Caucasian and Chinese subjects were included in this multicenter retrospective study. Subsequently, Chinese eyes were matched to Caucasians by age, intraocular pressure (IOP), and Corneal Thickness (CCT) using a case-control matching algorithm.

Risk Factors for Progression of Keratoconus and Failure Rate After Corneal Cross-linking.

Purpose: To assess the occurrence of risk factors for progression of keratoconus and failure rate after corneal cross-linking (CXL) in patients with progressive keratoconus.

Methods: This retrospective study observed 230 eyes of 173 patients with a minimum follow-up of 36 months after CXL. A total of 185 eyes underwent CXL once (80%) (control) and 45 (20%) underwent this treatment more than once (Re-CXL-group).

[Principles of corneal cross-linking : Presentation based on the development of the various treatment protocols].

Background: Corneal cross-linking (CXL) is used to treat corneal ectatic diseases. The aim is to improve the reduced consolidation of the cornea in order to halt further corneal protrusion and therefore subsequent deterioration of the optical imaging proportions.

Material And Methods: In this article the principles of corneal cross-linking based on riboflavin and UV light are presented including recent research results.

Agreement and repeatability of corneal tomography in healthy eyes using a new swept-source OCT, a rotating Scheimpflug camera, and a dual Scheimpflug-Placido system.

Purpose: To investigate the accordance and repeatability of tomographic parameters measured by a new swept-source optical coherence tomographer (SS-OCT, ANTERION), a rotating Scheimpflug camera (RSC, Pentacam), and a dual Scheimpflug-Placido system (DSP, Galilei G6).

Setting: Department of Ophthalmology of University of Hospital Carl Gustav Carus, Dresden, Germany.

Design: Prospective reliability analysis.

Development of a classification system based on corneal biomechanical properties using artificial intelligence predicting keratoconus severity.

Background: To investigate machine-learning (ML) algorithms to differentiate corneal biomechanical properties between different topographical stages of keratoconus (KC) by dynamic Scheimpflug tonometry (CST, Corvis ST, Oculus, Wetzlar, Germany). In the following, ML models were used to predict the severity in a training and validation dataset.

Methods: Three hundred and eighteen keratoconic and one hundred sixteen healthy eyes were included in this monocentric and cross-sectional pilot study.

Long term results of accelerated 9 mW corneal crosslinking for early progressive keratoconus: the Siena Eye-Cross Study 2.

Purpose: To assess clinical results of the 9 mW/5.4 J/cm accelerated crosslinking (ACXL) in the treatment of progressive keratoconus (KC) over a span of 5 years.

Methods: The prospective open non-randomized interventional study (Siena Eye-Cross Study 2) included 156 eyes of 112 patients with early progressive KC undergoing the Epi-Off 9 mW/5.

Comparison of waveform-derived corneal stiffness and stress-strain extensometry-derived corneal stiffness using different cross-linking irradiances: an experimental study with air-puff applanation of ex vivo porcine eyes.

Purpose: To assess corneal stiffening of standard (S-CXL) and accelerated (A-CXL) cross-linking protocols by dynamic corneal response parameters and corneal bending stiffness (Kc[mean/linear]) derived from Corvis (CVS) Scheimpflug-based tonometry. These investigations were validated by corneal tensile stiffness (K[ts]), derived from stress-strain extensometry in ex vivo porcine eyes.

Methods: Seventy-two fresh-enucleated and de-epithelized porcine eyes were soaked in 0.

[Scedosporium apiospermum-a rare pathogen of keratomycosis].

This article presents the case of a 44-year-old contact lens wearer who presented with acute keratitis resistant to antibacterial treatment in the right eye. The anterior segment of the eye showed circular conjunctival hyperemia, a corneal white cell infiltrate with radiating margins and a central corneal erosion. Microbiological investigation of a corneal scraping revealed growth of Scedosporium apiospermum.

Repeatability and reproducibility of corneal deformation response parameters of dynamic ultra-high-speed Scheimpflug imaging in keratoconus.

Purpose: To assess the repeatability and reproducibility of dynamic corneal response (DCR) parameters obtained by ultra-high-speed Scheimpflug imaging (Corvis ST); in keratoconic patients.

Setting: Clinics in Germany, Italy, and Brazil.

Design: Prospective, observational study.

Intraocular Pressure Measurement Using Ocular Response Analyzer, Dynamic Contour Tonometer, and Scheimpflug Analyzer Corvis ST.

Purpose: To compare intraocular pressure (IOP) measurements with Goldmann applanation tonometry (GAT), ocular response analyzer (ORA), dynamic contour tonometer (DCT), and Corvis ST (CST) in healthy subjects.

Methods: In a prospective, observational study, IOP measurements with GAT (GAT-IOPc), ORA (IOPcc), DCT (DCT-IOP), and CST (bIOP) were performed and analyzed in 94 healthy subjects.

Results: Mean age of the participants was 45.

[Statistical analysis of correlated measurement data in ophthalmology : Tutorial for the application of the linear mixed model in SPSS and R using corneal biomechanical parameters].

Background: In ophthalmology data from both eyes of a person are frequently included in statistical analyses. As correlated data are used this procedure contradicts the independency principle for classical statistical tests, such as Student's t‑test and analysis of variance (ANOVA). In this tutorial a new possibility is presented in which data from both eyes can be used for statistical analysis.

Assessment of corneal biomechanical parameters in healthy and keratoconic eyes using dynamic bidirectional applanation device and dynamic Scheimpflug analyzer.

Purpose: To investigate corneal biomechanical parameters in healthy and keratoconic eyes using the Ocular Response Analyzer dynamic bidirectional applanation device (ORA) and the Corvis ST dynamic Scheimpflug analyzer (CST).

Setting: Department of Ophthalmology, Carl Gustav Carus University Hospital Dresden, Germany.

Design: Prospective, monocentric, case-control study.

Posterior amorphous corneal dystrophy in a patient with 12q21.33 deletion.

Posterior amorphous corneal dystrophy (PACD) (OMIM 612868) is a rare autosomal dominant disorder characterized by partial or complete posterior lamellar corneal opacification, decreased corneal thickness and flattening of the corneal curvature. PACD is associated with heterozygous deletions in chromosome band 12q21.33 harboring DCN, KERA, LUM, and EPYC which encode small leucine-rich proteoglycans.