Nervous NDRGs: the N-myc downstream-regulated gene family in the central and peripheral nervous system.

The N-Myc downstream-regulated gene (NDRG) family consists of four members (NDRG1, NDRG2, NDRG3, NDRG4) that are differentially expressed in various organs and function in important processes, like cell proliferation and differentiation. In the last couple of decades, interest in this family has risen due to its connection with several disorders of the nervous system including Charcot-Marie-Tooth disease and dementia, as well as nervous system cancers. By combining a literature review with in silico data analysis of publicly available datasets, such as the Mouse Brain Atlas, BrainSpan, the Genotype-Tissue Expression (GTEx) project, and Gene Expression Omnibus (GEO) datasets, this review summarizes the expression and functions of the NDRG family in the healthy and diseased nervous system.

Emergent Treatment of Ruptured Axillary Artery Aneurysm.

The axillary artery aneurysm (AxAA) is a rare entity, with a diverse range of proposed etiologic mechanisms. Although usually asymptomatic, thromboembolic or hemorrhagic complications leave many with vascular and neurologic compromise. Both open and endovascular treatment approaches have been reported.