Publications by authors named "Rainier-Numa Georges"
Transketolases (TKs) are key enzymes of the pentose phosphate pathway, regulating several other critical pathways in cells. Considering their metabolic importance, TKs are expected to be conserved throughout evolution. However, Tittmann et al.
View Article and Find Full Text PDFVibrio vulnificus (vv) is a multidrug-resistant human bacterial pathogen whose prevalence is expected to increase over the years. Transketolases (TK), transferases catalyzing two reactions of the nonoxidative branch of the pentose-phosphate pathway and therefore linked to several crucial metabolic pathways, are potential targets for new drugs against this pathogen. Here, the vvTK is crystallized and its structure is solved at 2.
View Article and Find Full Text PDFArticle Synopsis
- - Fibrillar collagen molecules are initially formed as precursors called procollagens, which have large propeptide extensions; they can exist as either homo- or heterotrimers.
- - While collagen type I commonly appears as a heterotrimer with two α1 and one α2 chain, a homotrimer form with three α1 chains is also found in certain tissues and diseases.
- - Research identifies specific amino acid residues in the C-terminal propeptides of the chains that influence whether collagen will form homo- or heterotrimers, highlighting a natural mutation that changes this balance and showing how the α2 chain evolved to support heterotrimer formation.