Publications by authors named "Raimundo Lopes da Silva"
The development of a nanoparticulate system for the carrier antigen is now an important tool in the vaccination process, since a smaller number of doses is necessary for effective immunization. Thus, in this work a nanoparticulate system using polymers of chitosan and poly (methacrylic acid) (CS-PMAA) to adsorb the Vi antigen of Typhi was developed. CS-PMAA nanoparticles with different proportions of chitosan and poly (methacrylic acid) were obtained and reached sizes from 123.
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- Chitosan is gaining attention for its unique properties that enhance drug delivery, particularly in combating typhoid fever using Vi Antigen nanoparticles.
- This study involved obtaining and characterizing Vi Antigen through Infrared spectroscopy and Computational Chemistry, revealing key structural insights and interactions.
- Two interaction models were proposed for Chitosan and Vi Antigen, showing how they bind at a molecular level, highlighting crucial interactions between acetyl groups and various functional groups in Chitosan.