Use of dipyrone during pregnancy and risk of congenital anomalies: a systematic review.

Purpose: This study aimed to summarize the evidence on the teratogenic effects of dipyrone used during pregnancy.

Methods: Databases (MEDLINE, EMBASE, Cochrane Library, CINAHL, Web of Science, Lilacs, SciELO, SCOPUS, OasisBR, and OpenGray) were reviewed until September 2023. We included studies that compared pregnant women who used dipyrone during any gestational period with those who used other analgesics or did not use any analgesics during the same gestational period.