Publications by authors named "Raihan H Mirza"
Excessive dietary fat intake causes systemic metabolic toxicity, manifested in weight gain, hyperglycemia, and insulin resistance. In addition, carbohydrate utilization as a fuel is substantially inhibited. Correction or reversal of these effects during high-fat diet (HFD) intake is of exceptional interest in light of widespread occurrence of diet-associated metabolic disorders in global human populations.
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- Prostaglandin transporter (PGT) increases in hyperglycemic conditions, which may lead to reduced levels of the angiogenic factor PGE(2) and impair wound healing.
- In experiments, hyperglycemia heightened PGT expression in human endothelial cells, significantly reducing their migration and tube formation capabilities.
- In diabetic mice, inhibiting PGT improved wound healing time and enhanced vascular responses, suggesting targeting PGT could be a therapeutic strategy for diabetic foot ulcers.