Publications by authors named "Raichel Jacob"
Background: Rheumatoid arthritis is the commonest inflammatory joint disease, affecting nearly 1% of the adult population worldwide. Early and accurate diagnosis and prognosis of rheumatoid arthritis (RA) have become increasingly important. In the present study, we aimed to elucidate the relationships between hematological, biochemical, immunological and cytogenetic parameters in rheumatoid arthritis patients and healthy normal controls.
View Article and Find Full Text PDFAssessment of genotoxic and molecular mechanisms of cancer risk in smoking and smokeless tobacco users.
Mutat Res Genet Toxicol Environ Mutagen
June 2014
Article Synopsis
- - Tobacco use is common in developing countries like India, leading to studies on genetic damage in smokers and smokeless tobacco users in rural Tamilnadu.
- - Researchers assessed DNA damage through various tests including chromosome aberrations and micronucleus frequency on blood samples and buccal cells.
- - Findings showed increased genetic damage in tobacco users, with 17% having a specific XRCC1 gene variant and 19% having a p53 gene variant, both linked to higher cancer risk.
India has a long history of tobacco, which includes chewing tobacco and smoking tobacco in various forms. Initially, the smokeless tobacco chewing habit was seen among the majority of the farmers who cultivated tobacco; but in recent years, smokeless tobacco is available in many forms and is cheaper as well and hence it is widely being used among literate and illiterate people. The subjects of our study are living in hilly regions of Yerkaud in Salem district, South India.
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