Publications by authors named "Raiasa Kantemirova"
Article Synopsis
- The study aimed to compare the efficacy of flavocoxid and naproxen for treating moderate to severe osteoarthritis (OA) of the knee over 12 weeks in 220 subjects.
- Both treatments showed significant reductions in OA symptoms, with no overall differences in efficacy when considering all participants.
- However, post-hoc analyses identified specific patient subsets (older adults, males, and those with milder disease) where flavocoxid appeared to be more effective, especially with longer treatment duration.
Introduction: Flavocoxid is a novel flavonoid-based "dual inhibitor" of the 5-lipoxygenase (5-LOX) enzyme and the cyclooxygenase (COX) enzymes. This study was designed to compare the effectiveness and safety of flavocoxid to naproxen in subjects with moderate to severe osteoarthritis (OA) of the knee.
Methods: In this randomized, multicenter, double-blind study, 220 subjects were assigned to receive either flavocoxid (500 mg twice daily) or naproxen (500 mg twice daily) for 12 weeks.