Publications by authors named "Raianna F Fantin"

Article Synopsis
  • The study explores how vaccines specifically designed for the Omicron XBB.1.5 variant can generate effective B-cell responses, focusing on the antibody responses in individuals who received a monovalent vaccine.
  • Researchers analyzed immune responses from 603 plasmablasts, expressing 100 human monoclonal antibodies to assess their effectiveness against various SARS-CoV-2 variants.
  • Two specific monoclonal antibodies, M2 and M39, were identified; M2 targeted only XBB.1.5 while M39 could neutralize both XBB.1.5 and JN.1, highlighting the functional potential of variant-specific vaccines.
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Plasmodium vivax is a major challenge for malaria control due to its wide geographic distribution, high frequency of submicroscopic infections, and ability to induce relapses due to the latent forms present in the liver (hypnozoites). Deepening our knowledge of parasite biology and its molecular components is key to develop new tools for malaria control and elimination. This study aims to investigate and characterize a P.

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Five species of cause malaria in humans and two of them, and , pose the greatest threat. Rapid antigen detection tests (RADT) have been used for many years to diagnose and distinguish malaria caused by these two parasites. malaria can single-handedly be diagnosed using an RADT, which detects the unique specific histidine-rich protein 2 (HRP2).

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Peptide-based vaccines have demonstrated to be an important way to induce long-lived immune responses and, therefore, a promising strategy in the rational of vaccine development. As to malaria, among the classic vaccine targets, the Apical membrane antigen (AMA-1) was proven to have important B cell epitopes that can induce specific immune response and, hence, became key players for a vaccine approach. The peptides selection was carried out using a bioinformatic approach based on Hidden Markov Models profiles of known antigens and propensity scale methods based on hydrophilicity and secondary structure prediction.

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In the Amazon basin, indigenous forest-dwelling communities typically suffer from a high burden of infectious diseases, including malaria. Difficulties in accessing these isolated ethnic groups, such as the semi-nomadic Yanomami, make official malaria data largely underestimated. In the current study, we longitudinally surveyed microscopic and submicroscopic malaria infection in four Yanomami villages of the Marari community in the northern-most region of the Brazilian Amazon.

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