The development and maintenance of immunity against visceral leishmaniasis.

Understanding the development and maintenance of immunological memory is important for efforts to eliminate parasitic diseases like leishmaniasis. Leishmaniasis encompasses a range of pathologies, resulting from infection with protozoan parasites belonging to the subgenera and of the genus A striking feature of these infections is that natural or drug-mediated cure of infection generally confers life-long protection against disease. The generation of protective T cell responses are necessary to control infections.

Advancing Treatment for Leishmaniasis: From Overcoming Challenges to Embracing Therapeutic Innovations.

Protozoan parasite infections, particularly leishmaniasis, present significant public health challenges in tropical and subtropical regions, affecting socio-economic status and growth. Despite advancements in immunology, effective vaccines remain vague, leaving drug treatments as the primary intervention. However, existing medications face limitations, such as toxicity and the rise of drug-resistant parasites.

Rice with lower amylose content could have reduced starch digestibility due to crystallized resistant starch synthesized by linearized amylopectin.

Background: High resistant starch (RS) rice with a low glycemic index (GI) is digested more slowly, resulting in a slow increase in the postprandial blood glucose level. People with milled rice as a staple diet, and with sedentary lifestyles, are more prone to acquire type 2 diabetes in the long term. With an increasing population of diabetics worldwide, one possible solution is the development of rice-based, low-GI foods with high RS content rice.

Chemokines Signature and T Cell Dynamics in Leishmaniasis: Molecular insight and therapeutic application.

Leishmaniasis, caused by obligate intracellular parasites, poses a significant global health burden. The control of infection relies on an effective T cell-dependent immune response; however, various factors impede the host’s ability to mount a successful defence. Alterations in the chemokine profile, responsible for cell trafficking to the infection site, can disrupt optimal immune responses and influence the outcome of pathogenesis by facilitating parasite persistence.

Systemic acquired resistance inducing chemicals mitigate black scurf disease in potato by activating defense-related enzymes.

The potato, being an underground vegetable crop, faces consistent threats from soil- and tuber-borne fungal and bacterial pathogens. Black scurf and stem canker disease caused by the fungal pathogen Kuhn is a critical global concern in the potato cultivation system. In this study, we evaluated the disease mitigation potential of five systemic acquired resistance-inducing chemicals , salicylic acid, jasmonic acid, -aminobutyric acid, -aminobutyric acid and hydrogen peroxide (HO).

Attachment Wear in Different Clear Aligner Therapy: A Comparative Study.

Background: Because of its ease and visual attractiveness, clear aligner therapy has grown in popularity as an orthodontic treatment option. On the other hand, the results of therapy may be impacted by attachment wear. Comparing attachment wear in three distinct clear aligner systems-System A, System B, and System C-was the goal of this investigation.

Assessment of Accuracy of Implant Placement Using Surgical Stent Versus Conventional Technique.

Purpose: The aim of this study was to assess the accuracy of the implant placement using surgical stents versus conventional implant placement.

Materials And Methods: Twenty patients who reported to Rajarajeswari Dental College and Hospital were selected and they were randomly divided into two groups. In both the groups, the selection of the implant size was based on the ridge mapping.

Whether Present Era Demand Change in Pharmaceutical Promotional Ways to be More Eco- and Doctor-Friendly? An Observational Study.

Aim: Pharmaceutical promotion is the principal aspect of the healthcare system. In this study, we aimed to portray the opinion of doctors and medical representatives (MRs) on conventional pharmaceutical ways (usage of promotional or educational paper materials and physician drug samples) for pharmaceutical promotion.

Materials And Methods: In this cross-sectional observational study, data were collected from doctors and MRs across India using self-administered Google forms.

Comparative Analysis of Braces and Aligners: Long-Term Orthodontic Outcomes.

Objectives: The purpose of this retrospective study was to evaluate the long-term results of orthodontic treatment with traditional braces and Invisalign, with a particular emphasis on treatment length, patient satisfaction, correction of malocclusion, and long-term stability.

Methods: Between 2020 and 2022, individuals who had orthodontic treatment at a tertiary care center had their data analysed. Patients with mild to severe malocclusions treated with conventional braces or Invisalign between the ages of 12 and 18 met the inclusion criteria.

A Study on Materials Used and Longevity of Implant-Supported Prostheses.

Objective: This retrospective research was directed to investigate the longevity and maintenance requirements of implant-supported prostheses in subjects treated at a tertiary care center.

Methods: Patient records of individuals who received implant-supported prostheses between January 2018 and December 2020 were retrospectively analyzed. Demographic information, implant type, prosthetic design, and follow-up data were collected.

Comparative Analysis of Surgical Techniques for Wisdom Tooth Extraction.

Background: Wisdom tooth extraction often requires various surgical techniques due to differences in tooth position, root morphology, and patient characteristics. This research aims to compare traditional surgical extraction with minimally invasive techniques such as piezo surgery and laser-assisted extraction, as well as extraction with the aid of 3D imaging and navigation systems.

Methods: Patients requiring wisdom tooth extraction were randomly assigned to one of the surgical technique groups.

Retrospective Review of Tonsillectomy and Adenoidectomy Outcomes in Pediatric Patients: Complications and Recurrence Rates.

Objective: This retrospective review aimed to analyze the outcomes of tonsillectomy and adenoidectomy (T and A) procedures in pediatric patients, focusing on complications and recurrence rates.

Methods: Medical records of pediatric patients who underwent T and A were retrospectively reviewed. Data on patient demographics, preoperative indications, surgical techniques, intraoperative findings, postoperative complications, and recurrence rates were collected and analyzed.

Retrospective Analysis of the Effectiveness of Laser Therapy in the Treatment of Acne Scarring.

Objective: This retrospective analysis aimed to estimate the efficiency of laser therapy in the management of acne scarring, assessing changes in scar severity, patient satisfaction, and adverse events.

Methods: A cohort of 150 subjects with clinically diagnosed acne scarring who underwent laser therapy. Data were extracted from electronic medical records, and baseline characteristics, scar types, and management parameters were analyzed.

Analgesic Effect of Caudal and Abdominal Nerve Blocks among Children Undergoing Inguinal Surgeries: An Original Research.

Context: Pediatric inguinal surgeries sometimes cause considerable post-operative pain that requires effective analgesics. Caudal and abdominal nerve blocks may help this population with pain. It is uncertain how successful they are compared.

Edible mushrooms trending in food: Nutrigenomics, bibliometric, from bench to valuable applications.

The worldwide consumption, health-promoting and nutritional properties of mushrooms have been extensively researched over a decade. Although, wide range of edible mushrooms is still unexplored, which can be a valuable source of bioactive compounds in dietary supplements and biopharma industry. Mushrooms represent as dynamic source of nutrients lacking in food from plant or animal origin thus, considered as vital functional food utilized for prevention of numerous diseases.

Biological Control of Stem Rot of Groundnut Induced by sacc.

Stem rot of groundnut ( L.) caused by is the main threat to groundnut production, causing significant economic losses. The present study aims to provide an overview of the potentiality of (Tv), (Th), (Pf), and (Bs), applied either individually or in mixed combination, against (isolate SrBKN).

Colourful staples on your table: Unus ex genere suo.

The positive health benefits of colored staples have led to a significant increase in interest in them as healthy food ingredients. Numerous in vitro and in vivo studies have demonstrated that colored cereals are rich in antioxidants, carotenoids, and xanthophylls, which are widely used as natural additives in the food industry. Additionally, shifts in consumer preferences have led to a preference for nutritionally balanced diets over traditional high-energy ones.

Isolation and characterization of native antagonistic rhizobacteria against Fusarium wilt of chilli to promote plant growth.

In the eastern coastal regions of Odisha, wilt caused by f. sp. is an extremely damaging disease in chilli.

Evaluation of blood based quantitative PCR as a molecular diagnostic tool for post kala-azar dermal leishmaniasis (PKDL).

Background: Post kala-azar dermal leishmaniasis (PKDL) is a consequential dermal manifestation of visceral leishmaniasis (VL), serving as a parasite reservoir. The traditional diagnostic approach, which requires an invasive skin biopsy is associated with inherent risks and necessitates skilled healthcare practitioners in sterile settings. There is a critical need for a rapid, less invasive method for Leishmania detection.