Ternary complex of Kaempferol-Hydroxypropyl-β-Cyclodextrin-Liposomes against hepatocellular carcinoma: Preparation, validation, pharmacokinetics and efficacy studies.

Kaempferol (KP), a GRAS-certified phytomolecule enrolled in Phase I trials, is reported with various biological effects including anticancer activity. However, its poor pharmacokinetic profile limits the translational utility. Studies indicate that liposomes incorporating cyclodextrin inclusion complexes improves the bioavailability of hydrophobic drugs.

AB- and A-Type Boron(III)Subchlorins Derived from -Diethoxycarbonyltripyrrane: Synthesis and Photophysical Exploration.

The first direct fabrication of AB- and A-type B(III)subchlorins from ethoxycarbonyl-substituted tripyrrane has been realized by condensation with appropriate acid chlorides (benzoyl chloride, butyryl chloride, and ethyl chlorooxoacetate). The aliphatic acid chloride-based annulation reaction is new to subporphyrinoid chemistry. The phenyl ()- or -propyl ()-substituted derivatives could be oxidized to the corresponding B(III)subporphyrins upon refluxing with DDQ, whereas the triethoxycarbonyl moiety () was found to be resistant to oxidation and exhibits the most red-shifted absorption (587 nm) and emission (604 nm).

-Free Boron(III)subchlorin and Its μ-Oxo Dimer with Interacting Chromophores.

-free B(III)subchlorin has been realized exclusively for the first time from ethoxycarbonyl-substituted tripyrrane along with the first subchlorin dimer as its μ-oxo analogue via a facile one-pot approach. The subchlorin is highly stable toward oxidation; hence, it was not contaminated with the corresponding subporphyrin analogue . The subchlorin (56%) and its dimer (30%) exhibit singlet oxygen generation ability for the first time.

Third-order nonlinear optical investigations of meso-tetrakis(2,3,5,6-tetrafluoro-N,N-dimethyl-4-anilinyl)porphyrin and its metal complexes.

We report here the experimental investigation on third-order nonlinear optical parameters of 5,10,15,20-tetrakis(2,3,5,6-tetrafluoro-N,N-dimethyl-4-anilinyl)porphyrin and its various metal complexes, using Z-scan technique at 532 nm. The third-order nonlinear optical susceptibilities (χ(3)) were of the order 10(-12) esu and are compared through degenerate four wave mixing (DFWM). The operating mechanism is reverse saturable absorption (RSA) as the effective excited-state absorption cross-section was found higher than ground state absorption cross-section as well as the magnitude of nonlinear absorption coefficient was found decreasing with on-axis input intensity.