Publications by authors named "Rahul S Subbarayan"

Objectives/hypothesis: Human papillomavirus (HPV) is a DNA virus that causes cancer in multiple sites. Although sexual activity is the primary means of oropharyngeal HPV acquisition, studies suggest HPV transmission through occupational exposure from medical instruments and surgical fumes. We assess if aerosolization of HPV16 DNA via electrocautery places otolaryngologists at risk for exposure.

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Article Synopsis
  • - HPV is linked to the rise of oropharyngeal squamous cell carcinoma (OPSCC), and the immune microenvironment around these tumors is critical to the cancer development process.
  • - Both innate immunity (like macrophages and dendritic cells) and adaptive immunity (such as CD8+ T-cells) interact in ways that can fuel inflammation and tumor growth.
  • - Current research aims to better understand how these immune responses contribute to the development of HPV-related OPSCC.
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Importance: Data regarding outcomes after major head and neck ablation and reconstruction in the growing geriatric population (specifically ≥80 years of age) are limited. Such information would be extremely valuable in preoperative discussions with elderly patients about their surgical risks and expected functional outcomes.

Objectives: To identify patient and surgical factors associated with 30-day postoperative complications, 90-day mortality, and 90-day functional decline; to explore whether an association exists between the type of reconstructive procedure and outcome; and to create a preoperative risk stratification system for these outcomes.

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Objective: Health registries and discharge-level databases are powerful tools. Commonly used data sets include the Nationwide Inpatient Sample (NIS); Surveillance, Epidemiology, and End Results Program (SEER); National Cancer Database (NCDB); and American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP). This study investigated the frequency with which these resources are being used and categorized their contributions to literature.

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