Publications by authors named "Rahnuma Kazem"
Article Synopsis
- Some women trying to get pregnant with embryo transfers have a hard time, known as recurrent implantation failure (RIF), and doctors are looking for ways to help them.
- This study looked at whether a special type of medicine, called immunomodulators, could increase the chances of having a baby for women with RIF who were undergoing treatment.
- The results showed that women who took immunomodulators had a better chance of having a baby compared to those who only received standard treatment, with a live birth rate of 20.9% versus 15.8%.
Study Question: What is the association between serum progesterone levels on the day of frozen embryo transfer (FET) and the probability of live birth in women undergoing different FET regimens?
Summary Answer: Overall, serum progesterone levels <7.8 ng/ml were associated with reduced odds of live birth, although the association between serum progesterone levels and the probability of live birth appeared to vary according to the route of progesterone administration.
What Is Known Already: Progesterone is essential for pregnancy success.
Article Synopsis
- The study focuses on the impact of the ANXA5 M2 haplotype, a potential procoagulant biomarker, on pregnancy outcomes in couples undergoing IVF and evaluates the effectiveness of testing and treating with low molecular weight heparin (LMWH).
- Involving 103 IVF couples with the ANXA5 M2 haplotype, the study compares their live birth rates to 1000 unscreened couples, finding that ANXA5 M2 carriers had similar live birth rates to both the fertile comparison group and matched controls.
- Results showed that treated male carrier couples had a higher live birth incidence compared to female carrier couples, suggesting that the management protocol for treating ANXA5 M2 positive
Thrombophilia and impaired placental vasculature are a major cause of adverse pregnancy outcome. In 2007, a new hereditary factor for obstetric complications and recurrent pregnancy loss (RPL) was identified as a sequence variation in the core promoter of the annexin A5 gene, ANXA5, called the M2 haplotype. M2 carriership has been demonstrated in couples with recurrent miscarriage and its origin is embryonic rather than specifically maternal, confirmed by subsequent papers.
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