Chalcone Mannich base derivatives: synthesis, antimalarial activities against , and molecular docking analysis.

Development and discovery of new antimalarial drugs are needed to overcome the multi-resistance of parasites to commercially available drugs. Modifying the substitutions on the amine groups has been shown to increase antimalarial activities and decrease cross-resistance with chloroquine. In this study, we have synthesized several chalcone derivatives the substitution of aminoalkyl groups into the aromatic chalcone ring using the Mannich-type reaction.