Publications by authors named "Rahmi Cetinkaya"
Article Synopsis
- Mature microRNAs (miRNAs) are short RNA sequences crucial for regulating target RNAs post-transcriptionally, following a complex production process that starts in the nucleus and ends with their incorporation into RISC in the cytosol.
- The binding of these miRNAs to target mRNAs can either degrade the mRNA or inhibit translation, which affects protein production, but in some cases, it can enhance protein synthesis instead.
- Despite substantial research, there are still challenges in computationally predicting miRNA regulation, which is necessary for understanding the intricate miRNA-target interactions and could lead to advancements in the field.
MicroRNAs are RNAs of about 18-24 nucleotides in lengths, which are found in the small noncoding RNA class and have a crucial role in the posttranscriptional regulation of gene expression, cellular metabolic pathways, and developmental events. These small but essential molecules are first processed by Drosha and DGCR8 in the nucleus and then released into the cytoplasm, where they cleaved by Dicer to form the miRNA duplex. These duplexes are bound by the Argonaute (AGO) protein to form the RNA-induced silencing complex (RISC) in a process called RISC loading.
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