Publications by authors named "Rahme Safakli"
Article Synopsis
- The mitochondrial unfolded protein response (UPRmt) is a crucial signaling pathway that helps cells manage stress and maintain mitochondrial function, especially in the human heart under pressure overload.
- This study identifies the NRF2 transcription factor as a key player in activating UPRmt in heart cells during mitochondrial stress, suggesting that NRF2 is vital for this protective mechanism.
- The research proposes that targeting the NRF2-PGAM5-KEAP1 signaling pathway could offer new therapeutic strategies for treating cardiovascular diseases and other conditions linked to mitochondrial dysfunction.
To rapidly adapt to harmful changes to their environment, cells activate the integrated stress response (ISR). This results in an adaptive transcriptional and translational rewiring, and the formation of biomolecular condensates named stress granules (SGs), to resolve stress. In addition to this first line of defence, the mitochondrial unfolded protein response (UPRmt) activates a specific transcriptional programme to maintain mitochondrial homeostasis.
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