Lifestyle interventions for dementia risk reduction: A review on the role of physical activity and diet in Western and Asian Countries.

Dementia, is a critical global public health challenge with no effective pharmacological treatments. Recent research highlights the significant role of lifestyle interventions, particularly physical activity and dietary habits, in mitigating cognitive decline among the elderly and preventing the progression to dementia in individuals with Mild Cognitive Impairment (MCI). This comprehensive review explores the impact of physical exercise and dietary approaches on cognitive health, comparing strategies adopted in Western and Asian countries.

Potential of soybean-velvet bean combination tempe in improving cognitive function.

Velvet bean is a native Indonesian legume containing L-dopa, yet it remains underutilized. The aim of this study was to analyze the effects of different types of tempe (soybean, velvet bean, and their combination) on cognitive function, brain histology, dopamine levels, and serum β-amyloid in rats, as well as to identify the parameters most influencing cognitive function, including brain mass and volume, hippocampal neuron count, and dopamine and β-amyloid levels. An experimental study was conducted using a completely randomized design with one factor: the protein source of diet.

COL3A1 Gene Polymorphism and Its Impact on Female Pelvic Organ Prolapse.

Pelvic organ prolapse (POP) is a women's health problem in both developed and developing countries. Various studies have found that the occurrence of POP is related to the supporting structures of the pelvic floor, including type III collagen levels. Most studies reported no correlation between collagen 3 alpha 1 (COL3A1) rs1800255 gene polymorphism and the occurrence of POP.

Prevalence, Risk Factors, and Quality of Life of Knee Osteoarthritis in Urban Community in Indonesia: A COPCORD Study.

Aim: This study evaluates the prevalence, risk factors, and quality of life of patients with knee osteoarthritis (OA) in the Indonesian population.

Method: A cross-sectional study of 3597 adults (≥ 18 years old) was conducted in 2023 involving 15 different cities in Indonesia. Knee OA was classified according to the clinical ACR criteria.

Active and Passive Smoking as Catalysts for Cognitive Impairment in Rural Indonesia: A Population-based Study.

Objectives: Research indicates that active smokers are at risk of cognitive impairment. However, the correlation between chronic passive smoking and the risk of cognitive impairment remains underexplored. This study aimed to determine the association between smoking, passive smoking, and cognitive impairment and examined the dose-response effect.

The Impact of Being Present During Resuscitation on Family Members: A Scoping Review Protocol.

Background And Aims: Family members of patients who are undergoing resuscitation may experience complex psychological challenges, including anxiety, depression, or posttraumatic stress symptoms. Although several studies have identified positive experiences of family members who were given the option to be present during their loved one's resuscitation, the actual impact of family presence during resuscitation on family members remains elusive and needs to be explored comprehensively. This review aims to identify the impact of being present during the resuscitation event of adult patients in in-hospital settings on family members.

Meniran ( L.) embedded zeolitic imidazolate framework (ZIF-8) nanoparticle for cancer chemotherapy: supported molecular docking analysis.

Cancer is among the leading causes of mortality worldwide. Natural bioactive compounds like Meniran ( L.) have been the focus of extensive research due to their potent anticancer properties.

Childhood High Adiposity has no Advantage for Height in Adulthood: Cross-Sectional Studies in Indonesian Children to Young Adults.

Background: Childhood obesity is associated with faster linear growth; nonetheless, its benefit to the mature height of Indonesian children is questionable. This study aimed to evaluate the relationship between adiposity and height growth of Indonesian children, adolescents, and young adults aged 7 to 23 years.

Methods: Height and skinfolds at triceps, subscapular, suprailiac, and calf were measured in 2,520 children, adolescents, and young adults aged 7 to 23 years (boys = 1,116, girls = 1,404).

From the depths of the Java Trench: genomic analysis of Priestia flexa JT4 reveals bioprospecting and lycopene production potential.

Background: The marine environment boasts distinctive physical, chemical, and biological characteristics. While numerous studies have delved into the microbial ecology and biological potential of the marine environment, exploration of genetically encoded, deep-sea sourced secondary metabolites remains scarce. This study endeavors to investigate marine bioproducts derived from deep-sea water samples at a depth of 1,000 m in the Java Trench, Indonesia, utilizing both culture-dependent and whole-genome sequencing methods.

Problem nutrients in diet of under-five children and district food security status: Linear programming analyses of 37 stunting priority districts in Indonesia.

Background: In Indonesia, food security and dietary patterns varied by regions. This might lead to differences in problem nutrients (PN) and should be considered in developing local-specific food-based recommendations (FBRs) for stunting prevention.

Objectives: This study aims to identify PNs in diet of under-five children in selected 37 stunting priority districts in Indonesia and assess whether the number of PNs was associated with district food security status.

DABCO-Intercalated α-Zirconium Phosphate as a Latent Thermal Catalyst in the Reaction of Urethane Synthesis.

The mixture of hexamethylene diisocyanate (HDI) and butanol (BuOH) with the intercalation compound of 1,4-diazabicyclo[2.2.2]octane (DABCO) with α-zirconium phosphate (α-ZrP) has been evaluated as a latent thermal catalyst at varying temperatures.

A randomised survey of the quality of antibiotics and other essential medicines in Indonesia, with volume-adjusted estimates of the prevalence of substandard medicines.

The World Health Organization warns that substandard and falsified medicines threaten public health in low- and middle-income countries. However, medicine quality surveys are often small and unrepresentative of the market, and the true scale of the problem remains unknown. We conducted a large field survey of essential medicines in Indonesia, and investigated how weighting survey results by market volume altered estimates of medicine quality.

Development and Validation of an Instrument to Assess the Safe Use of Antidiabetic Medication to Prevent Hypoglycemia Requiring Hospitalization Among Ambulatory Patients with Type 2 Diabetes Mellitus.

Objectives: Ambulatory patients with type 2 diabetes mellitus (T2DM) require special attention when being discharged from the hospital with anti-diabetes medication. This necessity stems primarily from the risk of adverse drug reactions, particularly hypoglycemia. However, this risk is significantly influenced by the patients' knowledge and behavior regarding their medication use.

Factors associated with the incidence of low birth weight in Pontianak City, Indonesia.

Introduction: The weight of an infant at the time of birth is an indicator of its health. Infants with low birth weight (LBW) are at a higher risk of neonatal mortality and morbidity as well as stunted growth. Low birth weight (LBW) remains a public health concern in developing countries, such as Indonesia.

Dual anti-inflammatory activities of COX-2/5-LOX driven by kratom alkaloid extracts in lipopolysaccharide-induced RAW 264.7 cells.

Cyclooxygenase (COX) and lipoxygenase (LOX) enzymes play a pivotal role in producing pro-inflammatory eicosanoids, including prostaglandins (PGs) and leukotrienes (LTs), in the inflammation process. Mitragynine is a primary alkaloid contained in the kratom's leaves and has been reported to show anti-inflammatory activity by suppressing COX-2 mRNA translation to lowering PGs synthesis. In this study, the Kratom's alkaloid extract containing ~ 46% mitragynine was found to exhibit dual inhibition activity towards COX-2/5-LOX enzymes at concentrations below 25 ppm in the LPS-induced RAW 264.

Advanced Halal Authentication Methods and Technology for Addressing Non-Compliance Concerns in Halal Meat and Meat Products Supply Chain: A Review.

Religious beliefs have a significant impact on consumer preferences, particularly in relation to food choices. Islam, like other religions, imposes specific dietary guidelines, notably regarding meat and meat products. However, ensuring compliance with halal standards across the entire meat and meat products supply chain presents considerable challenges.

Advancements in green diesel production for energy sustainability: a comprehensive bibliometric analysis.

Green diesel as a second-generation biofuel has received enormous attention owing to the huge demand for renewable fuel for addressing the net zero target in 2050. This study examines the development of green diesel research through a bibliometric analysis. The state-of-the-art green diesel research is studied based upon 1285 documents (1153 articles and 132 reviews) retrieved from the Scopus database related to the used keywords.

Soluble adhesion molecules in serum and peritoneal fluid are associated with pelvic pain in endometriosis.

Objective: To investigate the association between soluble adhesion molecules (sE-cadherin, sE-selectin, sICAM-1, sVCAM-1) in serum and peritoneal fluid and pelvic pain in infertile women with endometriosis.

Methods: This observational study included 86 infertile women undergoing diagnostic laparoscopy, 43 of whom were diagnosed with endometriosis. Pain intensity was evaluated using the visual analog scale (VAS).

Family Self-management Program for Hypertension Management and Sodium Consumption Adherence: A Parallel Randomized Control Trial Among Family Caregivers and People With Hypertension.

Background: Hypertension (HTN) has become a serious health problem in developing countries. The family has an important role in maintaining blood pressure (BP) at home, and sodium diet compliance in people with HTN needs to be developed. Therefore, this research aimed to evaluate the effectiveness of a family self-management program (FSMP) in HTN management and compliance with sodium consumption in rural areas of Indonesia.

Value for money of medicine sampling and quality testing: evidence from Indonesia.

Background: Substandard and falsified medicines (SFMs) are a public health concern of global importance. Postmarket surveillance in the form of medicine sampling and quality testing can prevent and detect SFM, however, there is remarkably scarce evidence about the cost and value for money of these activities: how much do they cost and how effective are they in detecting SFM?

Methods: Between February and October 2022, Systematic Tracking of At Risk Medicines (STARmeds) collected and analysed for quality 1274 samples of 5 medicines from physical and online retail outlets in 7 Indonesian districts. We collated data on the resources consumed by STARmeds, related to all stages of medicines sampling and quality testing including design, fieldwork and laboratory analysis.

Correlation Between Insulin Resistance and Psoriatic Arthritis Disease Activity: A Cross-Sectional Study.

Objectives: Most psoriatic arthritis (PsA) research and studies focus solely on the skin and joint manifestations, but there is also an increased risk of metabolic disorders, including insulin resistance (IR). This study aims to discover the relationship between IR and disease activity (DA) in PsA and its phenotype.

Materials And Methods: Patients with PsA classified using the CASPAR criteria with the disease activity was measured using the DAPSA score, and IR was identified as an elevated HOMA-IR of >2.

Transrectal Ultrasound in Cervical Cancer: A Systematic Review of its Current Application.

Introduction: The use of transrectal ultrasound (TRUS) is established in prostate cancer but remains limited in cervical cancer. This systematic review aims to aggregate and describe the current use and advancements of TRUS in cervical cancer to identify gaps in the literature.

Methods: This study follows a protocol registered in the PROSPERO database (CRD42024520099).