Facial discoid dermatosis: A cosmetically disfiguring and challenging condition to treat.

Facial discoid dermatosis (FDD) is a recently described condition comprising discrete facial papulo-squamous lesions. We report three cases that clinically and histologically resemble FDD and demonstrate its resistance to treatment. Awareness of this new clinical entity will allow early diagnosis and the ability to make patients aware that there is unlikely to be a successful treatment.

Biomarkers of systemic treatment response in people with psoriasis: a scoping review.

Background: Responses to the systemic treatments commonly used to treat psoriasis vary. Biomarkers that accurately predict effectiveness and safety would enable targeted treatment selection, improved patient outcomes and more cost-effective healthcare.

Objectives: To perform a scoping review to identify and catalogue candidate biomarkers of systemic treatment response in psoriasis for the translational research community.

Biomarkers of disease progression in people with psoriasis: a scoping review.

Background: Identification of those at risk of more severe psoriasis and/or associated morbidities offers opportunity for early intervention, reduced disease burden and more cost-effective healthcare. Prognostic biomarkers of disease progression have thus been the focus of intense research, but none are part of routine practice.

Objectives: To identify and catalogue candidate biomarkers of disease progression in psoriasis for the translational research community.

Gravitational erythema.

We report a case of gravitational erythema in a 13-year-old boy who presented with a blotchy erythematous rash affecting his arms when hanging down and legs and lower abdomen on standing. The cutaneous symptoms in the upper limbs would resolve rapidly on elevation of the arms, whereas the lower limb rash would disappear on lying flat. Although this is a benign condition, no effective treatment has previously been reported.