Galactic cosmic ray environment predictions for the NASA BioSentinel Mission, part 2:Post-mission validation.

The BioSentinel CubeSat was deployed on the Artemis-I mission in November 2022 and has been continuously transmitting physical measurements of the space radiation environment since that time. Just before mission launch, we published computational model predictions of the galactic cosmic ray exposure expected inside BioSentinel for multiple locations and configurations. The predictions utilized models for the ambient galactic cosmic ray environment, radiation physics and transport, and BioSentinel geometry.

NEMS generated electromechanical frequency combs.

This paper presents a novel technique for low-power generation of frequency combs (FC) over a wide frequency range. It leverages modal interactions between electrical and mechanical resonators in electrostatic NEMS operating in air to provide a simple architecture for FC generators. A biased voltage signal drives the electrical resonator at resonance which is set to match an integer submultiple of twice the mechanical resonator's resonance.

The prevalence of malnutrition in children under 6 in Southern Iran from 2018 to 2023: a population-based study authors.

Background: Malnutrition, wasting, and obesity among children under 6 years old pose a serious global health concern, increasing the risk of various infectious and non-infectious diseases. Therefore, regular monitoring of these conditions is crucial. This study aimed to evaluate the prevalence of malnutrition in children under 6 years of age from 2018 to 2023.

Generation of Soliton Frequency Combs in NEMS.

In this study, we present an innovative approach leveraging combination internal resonances within a NEMS platform to generate mechanical soliton frequency combs (FCs) spanning a broad spectrum. In the time domain, the FCs take the form of a periodic train of narrow pulses, a highly coveted phenomenon within the realm of nonlinear wave-matter interactions. Our method relies on an intricate interaction among multiple vibration modes of a bracket-nanocantilever enabled by the strong nonlinearity of the electrostatic field.

Modelling Cellular Response to Ionizing Radiation: Mechanistic, Semi-Mechanistic, and Phenomenological Approaches - A Historical Perspective.

Radiation research is a multidisciplinary field, and among its many branches, mathematical and computational modelers have played a significant role in advancing boundaries of knowledge. A fundamental contribution is modelling cellular response to ionizing radiation as that is the key to not only understanding how radiation can kill cancer cells, but also cause cancer and other health issues. The invention of microdosimetry in the 1950s by Harold Rossi paved the way for brilliant scientists to study the mechanism of radiation at cellular and sub-cellular scales.

Modelling DNA damage-repair and beyond.

The paper presents a review of mechanistic modelling studies of DNA damage and DNA repair, and consequences to follow in mammalian cell nucleus. We hypothesize DNA deletions are consequences of repair of double strand breaks leading to the modifications of genome that play crucial role in long term development of genetic inheritance and diseases. The aim of the paper is to review formation mechanisms underlying naturally occurring DNA deletions in the human genome and their potential relevance for bridging the gap between induced DNA double strand breaks and deletions in damaged human genome from endogenous and exogenous events.

Postpartum depression and its relationship with the positive and negative perfectionism.

Background: Depression is a common mental disorder after childbirth, which has serious consequences for the mother, baby, and family. A wide range of causes, including some personality traits of mothers, are involved in its etiology. Therefore, this study was conducted aiming to determine the factors related to postpartum depression (PPD) and its relationship with positive and negative perfectionism in Qom, Iran.

[Considerable regional differences in patient injuries after primary hip and knee arthroplasty and between orthopedic departments depending on surgical volume].

Hip and knee arthroplasties are mostly successful procedures; however, patient injuries may occur and should be reported to Löf, the Swedish patient insurance. This study investigated the incidence of patient injuries after primary total hip and knee arthroplasty in the Swedish regions, differences in incidence depending on annual surgical volume, and types of approved injuries. Approved patient injuries were related to the total number of hip and knee arthroplasties registered in the Swedish Arthroplasty Register 2012-2021.

Unraveling the nature of sensing in electrostatic MEMS gas sensors.

This paper investigates the fundamental sensing mechanism of electrostatic MEMS gas sensors. It compares among the responsivities of a set of MEMS isopropanol sensors before and after functionalization, and in the presence and absence of electrostatic fields when operated in static and dynamic detection modes. In the static mode, we found that the sensors do not exhibit a measurable change in displacement due to added mass.

The forgotten girls: the state of evidence for health interventions for pregnant adolescents and their newborns in low-income and middle-income countries.

Every year, an estimated 21 million girls aged 15-19 years become pregnant in low-income and middle-income countries (LMICs). Policy responses have focused on reducing the adolescent birth rate whereas efforts to support pregnant adolescents have developed more slowly. We did a systematic review of interventions addressing any health-related outcome for pregnant adolescents and their newborn babies in LMICs and mapped its results to a framework describing high-quality health systems for pregnant adolescents.

The ENCODE Uniform Analysis Pipelines.

The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create a comprehensive catalog of functional elements in the human genome. The current database comprises more than 19000 functional genomics experiments across more than 1000 cell lines and tissues using a wide array of experimental techniques to study the chromatin structure, regulatory and transcriptional landscape of the and genomes. All experimental data, metadata, and associated computational analyses created by the ENCODE consortium are submitted to the Data Coordination Center (DCC) for validation, tracking, storage, and distribution to community resources and the scientific community.

Galactic cosmic ray environment predictions for the NASA BioSentinel mission.

BioSentinel is a nanosatellite deployed from Artemis-I designed to conduct in-situ biological measurements on yeast cells in the deep space radiation environment. Along with the primary goal of measuring damage and response in cells exposed during spaceflight, on-board active dosimetry will provide measurements of the radiation field encountered behind moderate shielding provided by the BioSentinel housing and internal components. The measurements are particularly important to enable interpretation of biological observations but also provide an opportunity to validate integrated computational models used to calculate radiation environments.

The ENCODE4 long-read RNA-seq collection reveals distinct classes of transcript structure diversity.

The majority of mammalian genes encode multiple transcript isoforms that result from differential promoter use, changes in exonic splicing, and alternative 3' end choice. Detecting and quantifying transcript isoforms across tissues, cell types, and species has been extremely challenging because transcripts are much longer than the short reads normally used for RNA-seq. By contrast, long-read RNA-seq (LR-RNA-seq) gives the complete structure of most transcripts.

The ENCODE Uniform Analysis Pipelines.

The Encyclopedia of DNA elements (ENCODE) project is a collaborative effort to create a comprehensive catalog of functional elements in the human genome. The current database comprises more than 19000 functional genomics experiments across more than 1000 cell lines and tissues using a wide array of experimental techniques to study the chromatin structure, regulatory and transcriptional landscape of the and genomes. All experimental data, metadata, and associated computational analyses created by the ENCODE consortium are submitted to the Data Coordination Center (DCC) for validation, tracking, storage, and distribution to community resources and the scientific community.

Galactic cosmic ray simulation at the NASA space radiation laboratory - Progress, challenges and recommendations on mixed-field effects.

For missions beyond low Earth orbit to the moon or Mars, space explorers will encounter a complex radiation field composed of various ion species with a broad range of energies. Such missions pose significant radiation protection challenges that need to be solved in order to minimize exposures and associated health risks. An innovative galactic cosmic ray simulator (GCRsim) was recently developed at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL).

Grazing and ecosystem service delivery in global drylands.

Grazing represents the most extensive use of land worldwide. Yet its impacts on ecosystem services remain uncertain because pervasive interactions between grazing pressure, climate, soil properties, and biodiversity may occur but have never been addressed simultaneously. Using a standardized survey at 98 sites across six continents, we show that interactions between grazing pressure, climate, soil, and biodiversity are critical to explain the delivery of fundamental ecosystem services across drylands worldwide.

Hyperelastic Microcantilever AFM: Efficient Detection Mechanism Based on Principal Parametric Resonance.

The impetus of writing this paper is to propose an efficient detection mechanism to scan the surface profile of a micro-sample using cantilever-based atomic force microscopy (AFM), operating in non-contact mode. In order to implement this scheme, the principal parametric resonance characteristics of the resonator are employed, benefiting from the bifurcation-based sensing mechanism. It is assumed that the microcantilever is made from a hyperelastic material, providing large deformation under small excitation amplitude.

Built-In Packaging for Single Terminal Devices.

An alternative packaging method, termed built-in packaging, is proposed for single terminal devices, and demonstrated with an actuator application. Built-in packaging removes the requirements of wire bonding, chip carrier, PCB, probe station, interconnection elements, and even wires to drive single terminal devices. Reducing these needs simplifies operation and eliminates possible noise sources.

Habitat potential modelling and mapping of Teucrium polium using machine learning techniques.

Determining suitable habitats is important for the successful management and conservation of plant and wildlife species. Teucrium polium L. is a wild plant species found in Iran.

Does the intensive grazing and aridity change the relations between the dominant shrub and plants under its canopies?

The interspecific plant interactions along grazing and aridity stress gradients represent a major research issue in plant ecology. However, the combined effects of these two factors on plant-plant interactions have been poorly studied in the northeast of Iran. To fill this knowledge gap, 144 plots were established in 12 study sites with different grazing intensities (high vs.

A multi-hazard map-based flooding, gully erosion, forest fires, and earthquakes in Iran.

We used three state-of-the-art machine learning techniques (boosted regression tree, random forest, and support vector machine) to produce a multi-hazard (MHR) map illustrating areas susceptible to flooding, gully erosion, forest fires, and earthquakes in Kohgiluyeh and Boyer-Ahmad Province, Iran. The earthquake hazard map was derived from a probabilistic seismic hazard analysis. The mean decrease Gini (MDG) method was implemented to determine the relative importance of effective factors on the spatial occurrence of each of the four hazards.

Effect of Various Irrigating Devices on the Removal of Two Different Forms of Calcium Hydroxide from Internal Resorption Cavities.

The present study aimed to investigate the efficiency of passive ultrasonic irrigation (PUI), EndoActivator (EA), standard needle irrigation (SNI), and XP-endo Finisher files in removing pure calcium hydroxide (pCH) and injectable CH from root resorption cavities. Using a rotary system, the root canals of 116 extracted single rooted teeth were prepared. Imitated internal resorption cavities were then created in root halves.

Efficient large amplitude primary resonance in in-extensional nanocapacitors: Nonlinear mean curvature component.

In general, the impact of geometric nonlinearity, which arises from geometric relationships governing the motion of constituent particles of elastic mediums, becomes critically important while the system operates under large deformations. In this case, the influence of different physics governing the system dynamics might be coupled with the impact of geometric nonlinearity. Here, for the first time, the non-zero component of the mean curvature tensor is nonlinearly expressed in terms of the middle-axis curvature of a cantilevered beam.