Exploring the Anticancer Effect of on Colorectal Cancer: Insights From Eight Colorectal Cancer Cell Lines.

Colorectal cancer (CRC) is a prevalent and deadly disease, necessitating the exploration of novel therapeutic strategies. Traditional chemotherapy often encounters drug resistance and adverse side effects, highlighting the need for alternative approaches. , a plant rich in phytochemical constituents, was investigated for its potential as an anticancer agent against colorectal cancer (CRC).

Dawn-to-dusk intermittent fasting is associated with overexpression of autophagy genes: A prospective study on overweight and obese cohort.

Aim And Background: A growing body of evidence supports the impact of intermittent fasting (IF) on longevity and healthy aging via the modulation of autophagy genes. The activation of the catabolic autophagic machinery (LAMP2, LC3B, ATG5, and ATG4D) has protective effects against degenerative aging and chronic diseases. This research examined the changes in the expression of the aforementioned genes upon the observance of dawn-to-dusk IF among metabolically healthy participants with overweight and obesity.

Serum 25 hydroxycholecalciferol in periodontitis patients with type 2 diabetes mellitus - A socioeconomic and clinicobiochemical study in Chhattisgarh.

Background: Very few studies have examined the impact of the concurrent presence of periodontitis (PD) and type 2 diabetes mellitus (T2DM) on serum Vitamin D levels, particularly in developing nations like India, and needs further investigation.

Aim: This study aims to assess the relationship between serum Vitamin D values and PD in T2DM patients and to study the correlation between socioeconomic and demographic variables that influence the serum Vitamin D levels and the extent of PD in patients with T2DM.

Materials And Methods: This was a cross-sectional, hospital-based research.

A new insight on the effects of Schiff Base Iron (III) complexes in breast cancer cells for clinical radiotherapy.

Purpose: Breast cancer is a significant global health concern, and researchers strive to enhance radiotherapy outcomes while minimizing the side effects. Schiff Base Iron (III) Complexes are one of the prospective elements that can be used as radiosensitizer or radioprotective agents in cancer radiotherapy. This study investigates the potential effects of Schiff base (ligand 2; L) with Fe(III) in MCF-7 breast cancer cells under clinical radiotherapy treatment.

Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations.

Microcephaly, Guillain-Barré syndrome, and potential sexual transmission stand as prominent complications associated with Zika virus (ZIKV) infection. The absence of FDA-approved drugs or vaccines presents a substantial obstacle in combatting the virus. Furthermore, the inclusion of pregnancy in the pharmacological screening process complicates and extends the endeavor to ensure molecular safety and minimal toxicity.

CO-19 PDB 2.0: A Comprehensive COVID-19 Database with Global Auto-Alerts, Statistical Analysis, and Cancer Correlations.

Biological databases serve as critical basics for modern research, and amid the dynamic landscape of biology, the COVID-19 database has emerged as an indispensable resource. The global outbreak of Covid-19, commencing in December 2019, necessitates comprehensive databases to unravel the intricate connections between this novel virus and cancer. Despite existing databases, a crucial need persists for a centralized and accessible method to acquire precise information within the research community.

SeasVeg: An image dataset of Bangladeshi seasonal vegetables.

Seasonal vegetables play a crucial role in both nutrition and commerce in Bangladesh. Recognizing this significance, our research introduces the 'SeasVeg' dataset, comprising images of ten varieties of seasonal vegetables sourced from Dhaka and Pabna regions. These include .

Paddy insect identification using deep features with lion optimization algorithm.

Pests are a significant challenge in paddy cultivation, resulting in a global loss of approximately 20 % of rice yield. Early detection of paddy insects can help to save these potential losses. Several ways have been suggested for identifying and categorizing insects in paddy fields, employing a range of advanced, noninvasive, and portable technologies.

Efficient production and purification of P radioisotope from sulfur by dry distillation: A practical approach with high radiochemical purity.

The P radioisotope, with a half-life of 14.3 days and an energy level of 1.71 MeV, has diverse applications in medicine and research.

The HABD: Home of All Biological Databases Empowering Biological Research With Cutting-Edge Database Systems.

The emergence of computer technologies and computing power has led to the development of several database systems that provide standardized access to vast quantities of data, making it possible to collect, search, index, evaluate, and extract useful knowledge across various fields. The Home of All Biological Databases (HABD) has been established as a continually expanding platform that aims to store, organize, and distribute biological data in a searchable manner, removing all dead and non-accessible data. The platform meticulously categorizes data into various categories, such as COVID-19 Pandemic Database (CO-19PDB), Database relevant to Human Research (DBHR), Cancer Research Database (CRDB), Latest Database of Protein Research (LDBPR), Fungi Databases Collection (FDBC), and many other databases that are categorized based on biological phenomena.

Quality Characteristics of Vegan Mayonnaise Produced Using Supercritical Carbon Dioxide-Processed Defatted Soybean Flour.

Emulsifiers, like egg yolk (EY), are necessary for the formation of mayonnaise, which is an oil-in-water type of colloid. This study aimed to assess the potential of defatted soybean powder treated with supercritical carbon dioxide (DSF) to enhance the quality of plant-based mayonnaise as plant-based alternatives gain popularity. This study involved the production of DSF and the comparison of its quality attributes to those of mayonnaise made with varying amounts of control soy flour (CSF), DSF, and EY.

Greening the grid: A comprehensive review of renewable energy in Bangladesh.

The escalating global demand for energy has coincided with economic development, while Bangladesh's reliance on renewable energy remains modest at 4.59%. Investigating economically viable solutions such as solar, biomass, and other renewable sources, the research underscores the pivotal role of sound policies and a strategic plan in transforming the current energy landscape.

BDWaste: A comprehensive image dataset of digestible and indigestible waste in Bangladesh.

The "BDWaste" dataset contains two significant categories of waste, namely digestible and indigestible, in Bangladesh. Each category represents 10 distinct species of waste. The digestible categories are sugarcane husk, fish ash, potato peel, paper, mango peel, rice, shell of malta, lemon peel, banana peel, and egg shell.

The role of Aquaporins in tumorigenesis: implications for therapeutic development.

Aquaporins (AQPs) are ubiquitous channel proteins that play a critical role in the homeostasis of the cellular environment by allowing the transit of water, chemicals, and ions. They can be found in many different types of cells and organs, including the lungs, eyes, brain, glands, and blood vessels. By controlling the osmotic water flux in processes like cell growth, energy metabolism, migration, adhesion, and proliferation, AQPs are capable of exerting their regulatory influence over a wide range of cellular processes.

Strategies of managing solid waste and energy recovery for a developing country - A review.

Solid waste is considered one of the major pollutants of both water and surface worldwide. The growing global population, urban expansion, and industrial growth are the main reasons for solid waste generation. This has become a major challenge with both regional and worldwide consequences.

Comprehensive analysis of the role of ubiquitin-specific peptidases in colorectal cancer: A systematic review.

Background: Colorectal cancer (CRC) is the third most frequent and the second most fatal cancer. The search for more effective drugs to treat this disease is ongoing. A better understanding of the mechanisms of CRC development and progression may reveal new therapeutic strategies.

Towards Understanding the Development of Breast Cancer: The Role of RhoJ in the Obesity Microenvironment.

Obesity is a growing pandemic with an increasing risk of inducing different cancer types, including breast cancer. Adipose tissue is proposed to be a major player in the initiation and progression of breast cancer in obese people. However, the mechanistic link between adipogenicity and tumorigenicity in breast tissues is poorly understood.

Protective effect of activated charcoal against progression of chronic kidney disease: A randomized clinical study.

Chronic kidney disease (CKD) is a non-reversible and progressive disease affecting the kidneys, significantly impacting global public health. One of the complications of chronic kidney disease is impaired intestinal barrier function, which may allow harmful products such as urea to enter the bloodstream and cause systemic inflammation. This study aimed to investigate whether supplementation with activated charcoal could reduce uremic toxins in patients with end-stage renal disease (ESRD).

Comparison of the effects of different artificial discs on hybrid surgery: A finite element analysis.

In recent years, artificial cervical discs have been used in intervertebral disc replacement surgery and hybrid surgery (HS). The advantages and disadvantages of different artificial cervical discs in artificial cervical disc replacement surgery have been compared. However, few scholars have studied the biomechanical effects of various artificial disc prostheses on the human cervical spine in HS which include the Anterior Cervical Discectomy and Fusion (ACDF) and Cervical Disc Arthroplasty (CDA).

A molecular dynamics simulations analysis of repurposing drugs for COVID-19 using bioinformatics methods.

A number of multidisciplinary methods have piqued the interest of researchers as means to accelerate and lower the cost of medication creation. The goal of this research was to find target proteins and then select a lead drug against SARS-CoV-2. The three-dimensional structure is taken from the RCSB PDB using its specific PDB ID 6lu7.

Identification of lead compound screened from the natural products atlas to treat renal inflammasomes using molecular docking and dynamics simulation.

One of the most prevalent ailments is kidney disease. Effective therapies for chronic renal disease are hard to come by. As a result, there is significant clinical and social interest to predict and develop novel compounds to treat renal disorders.