First-trimester Doppler Ultrasound for Predicting Successful Management of Pregnancy with Recurrent Pregnancy Losses Due to Antiphospholipid Syndrome and Thrombophilia: A Cohort Study.

Background: Recurrent pregnancy loss (RPL) often stems from a hypercoagulable state that exacerbates conditions such as antiphospholipid syndrome (APS) and thrombophilia, leading to early placental issues. Although treatments such as low-molecular-weight heparin (LMWH) and low-dose aspirin (LDA) are used, outcomes vary. This study proposes using first-trimester Doppler ultrasound - specifically, uterine radial artery resistance index (URa-RI) at 8 weeks and uterine artery pulsatility index (Ut-PI) with pre-diastolic notching (Ut-notch) at 11-13 weeks - to better predict successful pregnancies and reduce risks of adverse outcomes.

Cerebral collateral flow state in acute ischemic stroke correlates with clinical functional outcomes in non-thrombectomy patients.

Introduction: Hypoperfusion index ratio (HIR) measured by computerized tomography perfusion (CTP) has been shown to predict collateral flow state in acute ischemic stroke (AIS). Low HIR (<0.4) is indicative of good collateral flow state.

Development of Thermosensitive Mucoadhesive Gel Based Encapsulated Lipid Microspheres as Nose-to-Brain Rivastigmine Delivery System.

Alzheimer's disease (ALZ) is a neurodegenerative disease that damages neuronal cells and causes decline in cognitive abilities. Administration of cholinesterase inhibitor compounds is the primary choice in the treatment of ALZ, one of which is rivastigmine (RVT). Several routes of administration of RVT are available, such as oral and transdermal.

Metabolic-Engineering Approach to Enhance Vanillin and Phenolic Compounds in Ocimum Sanctum (CIM-Angana) via VpVAN Overexpression.

Transgenic Ocimum sanctum plants were engineered to produce vanillin by overexpressing the VpVAN gene using Agrobacterium-mediated transformation. Positive transformants developed shoots within 4-5 weeks and were transferred to a root induction medium and four independent transformants with no observed adverse effects were kept for anlysis. Quantitative RT-PCR indicated significantly higher VpVAN expression in transgenic lines AG_3 and AG_1, impacting the phenylpropanoid pathway and phenolic compound accumulation.

Influence of prey availability on the movement pattern of breeding saker falcons () in Mongolia.

As an apex predator in arid steppe, saker falcon plays a crucial role in maintaining ecosystem balance. Understanding their movement patterns concerning conspecific competition and prey availability is important for their conservation. We aim to understand how movement pattern of breeding saker falcons relates to prey availability.

Diosmin: A promising phytochemical for functional foods, nutraceuticals and cancer therapy.

Diosmin, a potent bioflavonoid derived from citrus fruits, has gained significant attention for its anticancer potential, reflecting a critical need in the ongoing battle against cancer. Amidst increasing cancer incidence, the quest for safer and more effective treatments has brought diosmin to the forefront, given its unique pharmacological profile distinct from other flavonoids. Diosmin's anticancer mechanisms are multifaceted, involving apoptosis induction, angiogenesis inhibition, and metastasis prevention.

Ag-Co ferrite-based magnetic polymeric composite film: a breakthrough in cationic dye remediation for sustainable environment.

The deployment of magnetically responsive and polymeric materials to remove dyes that are hazardous in aquatic environments has profoundly revolutionized environmental sustainability. This study focuses on removing the hazardous cationic Malachite Green (MG) dye from solutions, employing a novel magnetic composite film as an adsorbent, designated as AgCo FeO (ACFCeP). The composite was synthesized solvent casting, incorporating AgCo FeO nanoparticles and CeO into a cellulose acetate/polyvinylpyrrolidone (CA/PVP) polymer matrix.

A New Proton Transfer Complex Between 3,4-Diaminopyridine Drug and 2,6-Dichloro-4-nitrophenol: Synthesis, Spectroscopic Characterization, DFT Studies, DNA Binding Analysis, and Antitumor Activity.

The proton transfer (PT) complexation reaction between 3,4-diaminopyridine (3,4-DAP), an important drug, and 2,6-dichloro-4-nitrphenole (DCNP) was investigated experimentally and theoretically. The experimental results indicated a chemical reaction occurred because of a hydrogen bonding, followed by proton transfer from the DCNP to the 3,4-DAP in different polar media. The Benesi-Hildebrand equation was used to estimate the formation constant (), molar absorptivity (ε), and other physical parameters.

Metabolic engineering of hairy root cultures in for enhanced production of vanillin, 4-hydroxybenzoic acid, and vanillyl alcohol.

The flavor of vanilla is a complex blend of compounds, with vanillin as the most prominent, along with vanillyl alcohol and 4-hydroxybenzoic acid. Natural vanillin extracted from vanilla beans is expensive, so researchers use heterologous synthesis to produce nature-identical vanillin in plant hosts. Consequently, alternative traditional farming and gathering methods are required to bridge the significant disparity between supply and demand.

Kinetics and thermodynamics investigations of efficient and eco-friendly removal of alizarin red S from water via acid-activated leaf powder and its magnetic iron oxide nanocomposite.

The present work aimed to highlight an efficient, readily accessible, and cost-effective adsorbent derived from (DS) leaf powder for removing the environmentally hazardous dye "alizarin red S" (ARS) from hydrous medium. A variant of the adsorbent is activated via sulfuric acid and composited with magnetic iron oxide nanoparticles (DSMNC). Both adsorbents are thoroughly characterized using techniques such as Fourier transform infrared spectroscopy, point of zero charge, energy-dispersive X-ray spectroscopy, and scanning electron microscopy, which show that they have a porous structure rich in active sites.

The role of the supervisor in self-regulated learning in the clinical environment: BEME Guide No. 89.

Introduction: Self-regulated learning (SRL) in medical education is important for successful learning and safe patient care. However, supervisors may be unaware of behaviours that explicitly facilitate or inhibit their students' or residents' SRL, therefore this BEME review explores the role of the supervisor in SRL in clinical environments.

Methods: A qualitative systematic review using meta-aggregation was performed, seeking to draw on the knowledge of included studies and the participants those studies represent to create context-rich recommendations that are relevant and applicable to practice.

Maternal and neonatal outcome among women with early-onset preeclampsia and late-onset preeclampsia.

Objective: This study aimed to determine the differences in characteristics and outcomes of early-onset and late-onset Preeclampsia.

Methods: A retrospective cross-sectional study was conducted on female patients giving birth with preeclampsia admitted into the Department of Obstetrics and Gynecology of Dr. Hasan Sadikin Hospital Bandung from January 2020 to December 2022 who met the study criteria.

Utilization of android-based paediatric assessment triangle application as an emergency detection tool for children.

Objectives: To identify the effectiveness of an android-based paediatric assessment triangle application in emergency diagnostics.

Methods: The action research study was conducted in the emergency department of a hospital under the Ministry of Defence, Indonesia, located within the Ministry of Defence Rehabilitation Centre Complex, from April to December 2020 after approval from the ethics review committee of the Faculty of Nursing, Universitas Indonesia, Indonesia, employing quantitative and qualitative methods consisting of planning, acting, observing and reflecting stages. Emergency department nurses with at least D3 nursing graduation who were able to identify emergency status in children were included.

Polyethylene Terephthalate Microplastics Generated from Disposable Water Bottles Induce Interferon Signaling Pathways in Mouse Lung Epithelial Cells.

Microplastics (MPs) are present in ambient air in a respirable size fraction; however, their potential impact on human health via inhalation routes is not well documented. In the present study, methods for a lab-scale generation of MPs from regularly used and littered plastic articles were optimized. The toxicity of 11 different types of MPs, both commercially purchased and in-lab prepared MPs, was investigated in lung epithelial cells using cell viability, immune and inflammatory response, and genotoxicity endpoints.

Heterologous expression of ACC deaminase gene in Pelargonium graveolens showed elevated tolerance to chromium stress.

An essential aromatic plant, Pelargonium graveolens, does not grow well in areas where chromium contamination is a problem. Because of oxidative stress and the collapse of the photosynthetic system, crops frequently sustain severe damage. The production of excess ethylene, known as stress ethylene, which is detrimental to plant growth, the formation of roots, and early senescence, is also increased by heavy metal exposure.

Rupture Endometriomas Presenting as Acute Abdomen Infection in Hasty and Limited Resources Setting: A Pitfall Not to Miss - A Case Report.

Introduction: Abdominal pain is a diagnostic problem that requires immediate care and treatment for surgeons and gynecologists. The causes of abdominal pain in women of childbearing age range from benign and temporary to potentially life threatening. Rare etiologies such as spontaneous ruptured endometrioma are often not included in the radar of diagnosis due to their rarity and non-specific signs and symptoms in the patient.

Quality metrics for same day emergency care-Consensus of a multi-professional panel of experts using a modified Delphi process.

Same Day Emergency Care (SDEC) services are at the heart of recovery plans for Emergency Care in the National Health Service. There are no validated metrics for the quality of care in SDEC. The Society for Acute Medicine's Quality Improvement Committee invited to a three-stage modified Delphi process to gather metrics used by clinicians.

Age and sex-specific disability-free life expectancy in urban and rural settings of Bangladesh.

Background: Disability-free life expectancy (DFLE) has been used to gain a better understanding of the population's quality of life.

Objectives: The authors aimed to estimate age and sex-specific disability-free life expectancy (DFLE) for urban and rural areas of Bangladesh, as well as to investigate the differences in DFLE between males and females of urban and rural areas.

Methods: Data from the Bangladesh Sample Vital Statistics-2016 and the Bangladesh Household Income and Expenditure Survey (HIES)-2016 were used to calculate the disability-free life expectancy (DFLE) of urban and rural males and females in Bangladesh in 2016.

Development of eco-friendly biofilms by utilizing microcrystalline cellulose extract from banana pseudo-stem.

Banana pseudo-stem, often considered as an underutilized plant part was explored as a potential reinforced material to develop an eco-friendly biofilm for food packaging applications. In this study, Microcrystalline cellulose (MCC) was extracted from banana pseudo-stem by alkali and acid hydrolysis treatment. The extracted MCC was used as a reinforced material in different concentrated polyvinyl alcohol (PVA) matrix alone as well as both PVA and Carboxymethyl Cellulose (CMC) matrix to develop biofilm by solvent casting method.

The Formulation and Characterization of Wound Dressing Releasing S-Nitrosoglutathione from Polyvinyl Alcohol/Borax Reinforced Carboxymethyl Chitosan Self-Healing Hydrogel.

Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. Self-healing hydrogel mechanical properties were improved via polymer blends.