Publications by authors named "Rahmadani Puji Lestari"
Childhood acute lymphoblastic leukemia: Four years evaluation of protocols 2013 and 2016 in a single center in Indonesia, a lower-middle-income country.
Sutaryo Sutaryo Pudjo Hagung Widjajanto Sri Mulatsih Bambang Ardianto Alexandra Widita Swipratami Pangarso Rahmadani Puji Lestari
Pediatr Blood Cancer
November 2022
Background: The prognosis of childhood acute lymphoblastic leukemia (ALL) in Indonesia, a lower-middle-income country (LMIC), is lower than in high income countries (HICs). The Indonesian ALL2013 protocol resulted in too many toxic deaths (21%) and abandonments (11%). Therefore, we drafted an adapted protocol, ALL2016.
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- - The study investigates the relationship between collagen expression (COL1A1 and COL6A1) and the severity of penile curvature in children with hypospadias, a common congenital genital abnormality linked to a curvature called chordee.
- - Researchers analyzed tissue samples from 60 children, finding that collagen expression was significantly lower in patients with both distal and proximal hypospadias compared to healthy controls, indicating a potential link to the severity of the condition.
- - The findings suggest that abnormal collagen expression could contribute to the curvature severity in hypospadias, providing insight into the underlying pathophysiology of both conditions.