Development of the Forskolin Microemulsion Formula and its Irritation Test on Rabbits.

Objectives: This study aimed to develop a microemulsion formula that can increase the solubility and stability of forskolin and its safety for topical use.

Materials And Methods: The materials used for the development of the microemulsion formula were triglyceride oil, non-ionic surfactants, and polyethylene glycol (PEG) for cosurfactants, which were selected on the basis of the results of the forskolin solubility test using high performance liquid chromatography (HPLC). The microemulsion was formulated by the phase titration method.