Publications by authors named "Rahma Nabilla"
The high mutation rate at the D614G hotspot-furin cleavage site region increases the priming efficiency of the Spike protein by furin protease: analysis of Indonesian SARS-CoV-2 G614 variants obtained during the early COVID-19 pandemic.
Faris Muhammad Gazali Nastiti Wijayanti Mohamad Saifudin Hakim Endah Supriyati Eggi Arguni Rahma Nabilla
Virusdisease
May 2023
Unlabelled: D614G mutation plays a significant role in the transmissibility of SARS-CoV-2. Identification of other mutations related to D614G mutation within the Spike protein is pivotal as they might contribute to the pathogenicity of SARS-CoV-2. This study aims to analyze the mutation rate of furin cleavage site (FCS) region of Indonesian origin SARS-CoV-2 and to predict the effect of mutation against Spike priming efficiency by furin.
View Article and Find Full Text PDFEvolutionary dynamics of SARS-CoV-2 circulating in Yogyakarta and Central Java, Indonesia: sequence analysis covering furin cleavage site (FCS) region of the spike protein.
Nastiti Wijayanti Faris Muhammad Gazali Endah Supriyati Mohamad Saifudin Hakim Eggi Arguni Rahma Nabilla
Int Microbiol
August 2022
Article Synopsis
- SARS-CoV-2, the virus causing COVID-19, shows evolutionary changes in its furin cleavage site (FCS), which is important for how the virus infects cells.
- A study analyzed the FCS region of SARS-CoV-2 from patients in Yogyakarta and Central Java, Indonesia, identifying several mutations, particularly the D614G variant that became dominant by September 2020.
- The research highlights the evolutionary advantage of the D614G mutation, which may impact the virus's behavior and spread in these regions.
Article Synopsis
- * The study utilized a two-step RT-qPCR-HRM method to analyze six SARS-CoV-2 RNA samples, focusing on the D614G mutation in the Spike protein.
- * Results indicated that the new method successfully distinguished between D614 and G614 variants, with confirmation through Sanger sequencing, showcasing its effectiveness for ongoing mutation surveillance.