Publications by authors named "Rahini Kakumanu"
We investigated the cardiovascular effects of venoms from seven medically important species of snakes: Australian Eastern Brown snake (Pseudonaja textilis), Sri Lankan Russell's viper (Daboia russelii), Javanese Russell's viper (D. siamensis), Gaboon viper (Bitis gabonica), Uracoan rattlesnake (Crotalus vegrandis), Carpet viper (Echis ocellatus) and Puff adder (Bitis arietans), and identified two distinct patterns of effects: i.e.
View Article and Find Full Text PDFRussell's viper () venom causes a range of clinical effects in humans. Hypotension is an uncommon but severe complication of Russell's viper envenoming. The mechanism(s) responsible for this effect are unclear.
View Article and Find Full Text PDFArticle Synopsis
- Blood-feeding animals, like vampire bats, face challenges in obtaining blood meals due to the need to prevent clotting, which involves anticoagulation and vasodilation mechanisms.
- Despite extensive research on vampire bat anticoagulants, their potential vasodilatory mechanisms, particularly in their venom, have been largely overlooked.
- This study identifies a vampire bat-derived peptide similar to human CGRP that promotes vascular relaxation, enhancing blood flow to facilitate feeding, and highlights the potential for these venom components in drug development.