The Effect of Biofeedback on Constipation, Sleep, Depression, Anxiety and Quality of Life in Patients with Dyssynergic Defecation: a QUASI Experimental Study (Before and After Study).

Dyssynergic defecation(DD) is the inability to coordinate abdominal and anorectal muscle contraction during defecation. Patients with constipation often report poor quality of life, sleep issues, and increased risk of mood disorders. Biofeedback is a recommended treatment for DD.

Unlocking CO Activation With a Novel Ni-Hg-Ni Trinuclear Complex.

Compounds featuring bonds between mercury and transition metals are of interest for their intriguing/ambiguous bonding and scarcely explored reactivities. We report herein the synthesis and reactivities of the new compound [(POCOP)Ni]Hg, [NiHg], featuring a trinuclear Ni-Hg-Ni core (POCOP=κ,κ,κ-2,6-(i-PrPO)CH). [NiHg] reacts with CO to give the carbonate-bridged complex [NiCO].

Distinguishing the activity of flexor digitorum brevis and soleus across standing postures with deep learning models.

Background: Electromyographic (EMG) recordings indicate that both the flexor digitorum brevis and soleus muscles contribute significantly to the control of standing balance, However, less is known about the adjustments in EMG activity of these two muscles across different postures.

Research Question: The purpose of our study was to use deep-learning models to distinguish between the EMG activity of the flexor digitorum brevis and soleus muscles across four standing postures.

Methods: Deep convolutional neural networks were employed to classify standing postures based on the temporal and spatial features embedded in high-density surface EMG signals.

Effect of low-frequency blood glucose self-monitoring on glycosylated hemoglobin levels among older adults with type 2 diabetes mellitus.

Background: Reducing the frequency of self-monitoring of blood sugar, due to needle phobia, pain, stress, and costs associated with the procedure, can improve patient compliance and quality of life, provided that adequate blood sugar control is maintained. This study aimed to evaluate the effect of low-frequency blood glucose self-monitoring (LFBGSM) on glycosylated hemoglobin (HbA1) levels among older adults living with type 2 diabetes mellitus (T2DM), treated with or without insulin.

Materials And Methods: This randomized controlled trial with a parallel design was conducted on 121 older adults with T2DM in Sabzevar, Iran, between 2018 and 2020.

Distinguishing among standing postures with machine learning-based classification algorithms.

The purpose of our study was to evaluate the accuracy with which classification algorithms could distinguish among standing postures based on center-of-pressure (CoP) trajectories. We performed a secondary analysis of published data from three studies: Study A) assessment of balance control on firm or foam surfaces with eyes-open or closed, Study B) quantification of postural sway in forward-backward and side-to-side directions during four standing-balance tasks that differed in difficulty, and Study C) an evaluation of the impact of two modes of transcutaneous electrical nerve stimulation on balance control in older adults. Three classification algorithms (decision tree, random forest, and k-nearest neighbor) were used to classify standing postures based on the extracted features from CoP trajectories in both the time and time-frequency domains.

Evaluation of the thyroid and hypothyroid function after postoperative radiation therapy among breast cancer patients.

Background: The current advances in radiotherapy (RT) have improved the outcome of breast cancer (BC) patients. Despite its therapeutic benefits, the iatrogenic toxicities of RT and its impact on BC survivors are still debated, and further evaluations should be considered. This study aims to assess the rate of subclinical hypothyroidism and hypoparathyroidism among BC patients who were exposed to therapeutic radiation.

A Longitudinal Examination of Blood Sugar Dynamics in Diabetes and Non-Diabetes Using Growth Curve Model: The Sabzevar Persian Cohort Study.

Background: Diabetes mellitus is a chronic metabolic disorder with substantial implications for public health. Understanding the factors influencing blood sugar fluctuations is crucial for effective diabetes management and prevention. This study aimed to evaluate factors associated with blood sugar changes in diabetic patients and healthy individuals attending the Sabzevar Persian Cohort Center, employing the growth curve model.

Cross-sectional study of determinants of undernutrition among children aged 6-36 months in Kabul, Afghanistan.

Objectives: The current study aimed to find the distribution and factors associated with undernutrition among children aged 6-36 months in Kabul.

Design: Cross-sectional study.

Setting: Public Ataturk Children's Hospital, Kabul.

Additive Anticonvulsive Effects of Sumatriptan and Morphine on Pentylenetetrazole-Induced Clonic Seizures in Mice.

Background And Purpose: Sumatriptan protects the brain from damage and enhance the anti-seizure effect of morphine. There is evidence that nitric oxide (NO) may mediate these effects of both drugs. In the present study, we investigated the effects of sumatriptan (0.

An unusual presentation of severe obstructive sleep apnea with nocturnal seizure-like movements: A case report.

Key Clinical Message: This study suggests that severe obstructive sleep apnea can present as sleep-related epileptic or non-epileptic seizures. A detailed history and physical examination, along with polysomnography and video electroencephalography findings can lead to the correct diagnosis.

Abstract: Obstructive sleep apnea (OSA) is defined by recurrent episodes of the upper airway complete or partial collapse while sleeping.

A decade of tobacco control efforts: Implications for tobacco smoking prevalence in Eastern Mediterranean countries.

Background And Objectives: This study aimed to assess the association between the 10-year implementation of tobacco control policies, cigarette affordability index and changes in tobacco smoking prevalence across Eastern Mediterranean (EMR) countries.

Materials And Methods: An ecologic study was conducted using EMR countries as the analytical unit. Data from three sources were utilized: the MPOWER scale to measure tobacco control policy implementation (2010-2020), the tobacco affordability index (expressed as a percentage of GDP per capita required to purchase 2000 cigarettes, from 2010 to 2020), and national tobacco smoking prevalence data for EMR countries (2010-2023).

Investigation of electro-vascular phase-amplitude coupling during an auditory task.

Multimodal neuroimaging using electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) provides complementary views of cortical processes, including those related to auditory processing. However, current multimodal approaches often overlook potential insights that can be gained from nonlinear interactions between electrical and hemodynamic signals. Here, we explore electro-vascular phase-amplitude coupling (PAC) between low-frequency hemodynamic and high-frequency electrical oscillations during an auditory task.

Endoscopic Versus Microscopic Stapedotomy: A Randomized Clinical Trial.

Objective: To determine the outcomes and complications of endoscopic versus microscopic stapes surgery in patients with otosclerosis.

Study Design: Randomized, single-blinded clinical trial.

Methods: Patients with otosclerosis who underwent either trans-canal microscopic or endoscopic stapedotomy at a tertiary care hospital were compared.

Context-aware Multimodal Auditory BCI Classification through Graph Neural Networks.

The prospect of electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) in the presence of topological information of participants is often left unexplored in most of the brain-computer interface (BCI) systems. Additionally, the usage of these modalities together in the field of multimodality analysis to support multiple brain signals toward improving BCI performance is not fully examined. This study first presents a multimodal data fusion framework to exploit and decode the complementary synergistic properties in multimodal neural signals.

Calreticulin Regulates SARS-CoV-2 Spike Protein Turnover and Modulates SARS-CoV-2 Infectivity.

Cardiovascular complications are major clinical hallmarks of acute and post-acute coronavirus disease 2019 (COVID-19). However, the mechanistic details of SARS-CoV-2 infectivity of endothelial cells remain largely unknown. Here, we demonstrate that the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) protein shares a similarity with the proline-rich binding ena/VASP homology (EVH1) domain and identified the endoplasmic reticulum (ER) resident calreticulin (CALR) as an S-RBD interacting protein.

Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury.

Chronic kidney disease (CKD) is characterized by the accumulation of uremic toxins and renal tubular damage. Tryptophan-derived uremic toxins [indoxyl sulfate (IS) and kynurenine (Kyn)] are well-characterized tubulotoxins. Emerging evidence suggests that transmembrane and immunoglobulin domain-containing 1 (TMIGD1) protects tubular cells and promotes survival.

A Comprehensive Review on Ensemble Solar Power Forecasting Algorithms.

With increasing demand for energy, the penetration of alternative sources such as renewable energy in power grids has increased. Solar energy is one of the most common and well-known sources of energy in existing networks. But because of its non-stationary and non-linear characteristics, it needs to predict solar irradiance to provide more reliable Photovoltaic (PV) plants and manage the power of supply and demand.

The effect of cannabidiol on seizure features and quality of life in drug-resistant frontal lobe epilepsy patients: a triple-blind controlled trial.

Background: Treatment-resistant epileptic seizures are associated with reduced quality of life (QoL). As polypharmacy with routine antiseizure medications has many side effects, novel add-on treatments are necessary. Recent research showed the efficacy of add-on therapy by cannabidiol (CBD) on refractory epilepsy.

Gastroprotective effect of sumatriptan against indomethacin-, stress- and ethanol-induced gastric damage in male rats: Possible modulatory role of 5-hydroxytryptamine 1B/1D receptors and pro-inflammatory cytokines.

The current study was aimed to investigate the beneficial effect of sumatriptan, a 5-hydroxytryptamine 1B/1D (5HT ) receptor agonist, on gastric ulcer in rats via stimulating 5HT receptors and suppressing pro-inflammatory cytokines. Rats were allocated into three models of gastric ulcer: indomethacin (30 mg/kg, PO), water immersion restraint stress (WRS) and ethanol (5 ml/kg PO). Animals were administered with sumatriptan (0.