A development of a gelatin and sodium carboxymethyl cellulose hydrogel system for dual-release transdermal delivery of lidocaine hydrochloride.

This study introduces a dual-release transdermal drug delivery system using a hydrogel matrix of cross-linked gelatin and sodium carboxymethyl cellulose (NaCMC). Designed for immediate drug release from microneedles (MNs) and sustained release from microcapsules (MCs), this system utilizes lidocaine hydrochloride as the model drug. The fabrication process involved casting the hydrogel into MN molds, with MCs embedded in the backing layer, establishing a dual-release mechanism.

Novel PLA/ZnO Nanofibrous Nanocomposite Loaded with Tranexamic Acid as an Effective Wound Dressing: and Assessment.

Background: Chronic wounds contribute to the majority of clinical cases, associated with significant morbidity, and place a massive financial burden on healthcare systems. Thus, various bandage mats have been designed to facilitate wound healing in clinical applications. Polylactic acid (PLA) nanofibers, as suitable drug carriers, are highly desirable to prepare a controlled environment for wound healing in dressing tissue.

Seroepidemiology of HTLV-1 and HTLV-2 Infection in Neyshabur City, North-Eastern Iran, during 2010-2014.

Background: Retroviruses of human T-lymphotropic viruses (HTLV-1 and HTLV-2) have been demonstrated to be endemic in the north-eastern region of Iran. This study was aimed to determine the HTLV-1 and HTLV-2 prevalence among healthy individuals in Neyshabur City during 2010-2014.

Methods: A total of 8054 blood samples were collected from healthy participants in Neyshabur, North-Eastern Iran.

Durable antibacterial and cross-linking cotton with colloidal silver nanoparticles and butane tetracarboxylic acid without yellowing.

Colloidal nano silver was applied on the surface of cotton fabric and stabilized using 1,2,3,4-butanetetracarboxylic acid (BTCA). The two properties of antimicrobial activity and resistance against creasing were imparted to the samples of fabric as a result of the treatment with silver nano colloid and BTCA. The antimicrobial property of samples was evaluated using two pathogenic bacteria including Escherichia coli and Staphylococcus aureus as outstanding barometers in this field.

Photo induced silver on nano titanium dioxide as an enhanced antimicrobial agent for wool.

In this study an effective nanocomposite antimicrobial agent for wool fabric was introduced. The silver loaded nano TiO(2) as a nanocomposite was prepared through UV irradiation in an ultrasonic bath. The nanocomposite was stabilized on the wool fabric surface by using citric acid as a friendly cross-linking agent.

Characterization of Molecular Evolution in Multi-Drug Resistant of Mycobacterium tuberculosis by rpoB Gene in Patient with Active Pulmonary Tuberculosis from Iranian Isolates.

This is the first genetic biodiversity study of Mycobacterium tuberculosis in Iran. Thus, we investigated the genetic patterns of strains isolated in the first survey of anti-tuberculosis drug-resistance by rpoB gene as part of the Global Project of Anti-tuberculosis Drug Resistance Surveillance (IAU, Iran). A 411-bp fragment of the rpoB gene, containing the sequence of the 81-bp rpoB fragment, was amplified by PCR and the rpoB gene fragments of tuberculosis strains were sequenced using the Amersham auto sequencer.