Publications by authors named "Rahima Tahir"
Article Synopsis
- Amphotericin B (AMPH), an anti-fungal drug, has been identified in this study for its potential use as an antibacterial agent, showcasing an innovative repurposing of the drug.
- The study highlights AMPH's mode of action through its interactions with Penicillin Binding Protein 2a (PBP 2a), essential for bacterial cell wall synthesis, indicating significant effects on the protein's structure and dynamics.
- Molecular dynamics simulations and analysis reveal that AMPH binding alters the conformational integrity of PBP 2a, enhancing its antibacterial properties, thus supporting the drug's potential in treating bacterial infections.
