The effect of genetic polymorphisms of AKT1 on PE susceptibility: a case-control study and insilico analysis.

Background: Preeclampsia (PE) is a gestational disease associated with developing hypertension and proteinuria.

Aim: This study investigated the effects of polymorphisms, a key enzyme in cellular signal transmission that regulates various cellular processes associated with PE.

Methods: The PCR-RFLP method was employed to genotype rs2494732, rs1130233, and rs1130214 polymorphisms.

The effects of rs10754558 and rs4612666 polymorphisms on preeclampsia susceptibility, onset, and severity: a case-control study and in silico analysis.

Preeclampsia (PE) is one of the serious complications of pregnancy and its exact etiology is unknown. Inflammasomes are multiportion complexes whose relation with PE has been described. Evidence showed the effect of NLRP3 inflammasome in PE pathogenesis.