Effects of microinjection of angiotensin II and captopril into nucleus accumbens on morphine self-administration in rats.

With an aim to investigate the effects of injection of angiotensin II (Ang II) and captopril into the nucleus accumbens (NAC) on morphine self-administration, male Wistar rats were first trained to receive small pellets of food by pressing the active lever in self-administration apparatus. The animals, divided into 4 groups (saline, morphine, captopril and Ang II) were placed in self-administration apparatus and were allowed to self-administer morphine (0.5 mg per infusion all test groups) or saline (saline group) during consecutive days, for 2 h/sessions.