Publications by authors named "Raheela Charania"
Article Synopsis
- Researchers have identified calcium-dependent protein kinase 1 (CDPK1) in the protozoan responsible for cryptosporidiosis as a promising target for new therapies.
- A specific compound, a pyridopyrimidinone, was found to effectively inhibit CdPK1 and prevent the growth of various strains of the parasite in host cells.
- Although the compound showed low systemic exposure after oral dosing, it achieved high concentrations in the gastrointestinal tract and demonstrated some effectiveness in animal models of the disease.
In a previous study, we observed an increase in the severity of cryptosporidial infection corresponding to decreased levels of short-chain fatty acids (SCFAs). Therefore, we decided to examine the effect of SCFAs on Cryptosporidium growth in human ileocecal adenocarcinoma (HTC-8) cells. HTC-8 cells were infected with 1 × 105 C.
View Article and Find Full Text PDFspp. are opportunistic protozoan parasites that infect epithelial cells of the small intestine, causing diarrheal illness in humans. Differences in severity may be due to the immunological status of the host, malnutrition or prior exposure but may also be due to differences in the host gut flora.
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