Publications by authors named "Rahat Ul-Ain"

Background: To enhance the quality of care available for children with central nervous system (CNS) tumors across the world, a systematic evaluation of capacity is needed to identify gaps and prioritize interventions. To that end, we created the pediatric neuro-oncology (PNO) resource assessment aid (PANORAMA) tool.

Methods: The development of PANORAMA encompassed 3 phases: operationalization, consensus building, and piloting.

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Hodgkin lymphoma with vanishing bile duct syndrome is a rare paraneoplastic syndrome and has never been studied in the pediatric population. The objectives of this study were to determine the clinical characteristics of this rare condition in children through a literature review, and a descriptive analysis of all published cases with the index case report. All reported cases fulfilling the inclusion criteria were found through a literature search, and analyzed in descriptive statistics.

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  • There is limited data on cancers associated with primary immunodeficiencies (PIDs) in children in low-middle-income countries, so this study examined their incidence and outcomes in Pakistan.
  • Out of 5,748 children with cancers, only eight had PID-associated malignancies, resulting in an incidence rate of 1.4 per 1,000, with a median diagnosis age of 6.5 years and a 7:1 male-to-female ratio.
  • The prognosis for these patients was poor, with a median survival of only 3.5 months, primarily due to infection-related deaths; the study suggests improved awareness and screening for PIDs might enhance treatment outcomes.
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  • The management of medulloblastoma in children has evolved significantly over the last 40 years, focusing on chemotherapy to enhance survival and lessen the harmful effects of high-dose craniospinal radiation.
  • Advances in molecular biology have led to improved staging and treatment strategies for this complex disease, moving beyond the previous reliance on the modified Chang's system.
  • This review discusses the progression of systemic therapies for treating medulloblastoma.
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Superior mediastinal syndrome secondary to an anterior mediastinal mass can be seen in acute lymphoblastic leukaemia (ALL) of T-cell lineage. We report a 3-year-old child with B-cell ALL, who presented with the superior mediastinal syndrome. The CT scan chest showed a huge anterior mediastinal mass and the peripheral blood immunophenotyping showed B-cell ALL.

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Down syndrome (DS) is the commonest chromosomal disorder and is considered to be the most common syndrome associated with acute leukaemia. The objective of this study was to determine the characteristics of acute leukaemia in children with DS in Pakistan. It was a retrospective, cohort study conducted over a 2-year period, and the data was analysed in SPSS 20.

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Electroencephalogram (EEG) is widely used for the diagnosis of neurological conditions like epilepsy, neurodegenerative illnesses and sleep related disorders. Proper interpretation of EEG recordings requires the expertise of trained neurologists, a resource which is scarce in the developing world. Neurologists spend a significant portion of their time sifting through EEG recordings looking for abnormalities.

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Lymphoblastic lymphoma and chronic myeloid leukaemia (CML) are two distinct neoplasms with different pathogenesis and clinical presentation. We hereby share a challenging case of a child presenting with fever, leucocytosis, generalised lymphadenopathy and massive splenomegaly. He was diagnosed as having novel association of concurrent T-lymphoblastic lymphoma diagnosed on cervical lymph node biopsy with BCR-ABL negative CML on bone marrow aspirate.

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