Identification of a novel pathogenic variant in and genes by a multigene sequencing panel in triple negative breast cancer in Morocco.

Pathogenic variants (PVs) in genes have been mainly associated with an increasing risk of triple negative breast cancer (TNBC). The contribution of PVs in non-BRCA genes to TNBC seems likely since the processing of homologous recombination repair of double-strand DNA breaks involves several genes. Here, we investigate the susceptibility of genetic variation of the and non- genes in 30 early-onset Moroccan women with TNBC.

Catamenial cyclic vomiting syndrome responding to oestrogen therapy: an adolescent case report.

Cyclic vomiting syndrome (CVS) is defined by episodes of vomiting lasting from a few hours to several days, alternating with periods of no symptoms. Various symptoms can be associated with vomiting such as nausea, migraine or abdominal pain. Common triggers of CVS include infection, psychological stress and menstruation.

[Posterior reversible encephalopathy syndrome: a case report].

Posterior reversible encephalopathy syndrome (PRES) is a radioclinical entity associating a reversible central nervous system involvement with a common brain imaging feature. There is a great variability in the clinical presentation of this syndrome and in the features of its sometimes atypical imaging appearance. PRES is an unusual neurological complication occurring during pregnancy or in the post-partum period, other than any pre-existing pathology occurred during pregnancy.

[Ballantyne syndrome complicated by eclampsia: about a case and literature review].

Ballantyne syndrome or preeclampsia (Mirror syndrome) is a rare clinical entity. Ethiopathogenesis is still poorly elucidated. Diagnosis must be suspected in patients with maternal edematous syndrome associated with fetal anasarca.

Villoglandular papillary adenocarcinoma: case report.

Villoglandular papillary adenocarcinoma (VPA) is a very rare subtype of adenocarcinoma of the uterine cervix, but a well-recognized variant of cervical adenocarcinoma with a favorable prognosis and generally occurring in women of child-bearing age. Herein, we report a case of VPA diagnosed and managed successfully with conservative measure. This management is particularly desirable in young women to preserve reproductive capability.

[Pseudo-tumoral peritoneal tuberculosis mimicking ovarian cancer: an important differential diagnosis to consider].

Peritoneal tuberculosis is a curable infectious disease that can simulate advanced ovarian cancer, leading to extensive and unnecessary surgical procedures commonly performed on women of reproductive age. We report a new case of pseudo-tumoral peritoneal tuberculosis in a 43-year old female patient with suspected ovarian cancer associated with peritoneal carcinomatosis. The diagnosis of peritoneal tuberculosis was based on exploratory laparotomy with extemporaneous histological examination.

[Utility of hCG dosage in the management of gestational trophoblastic diseases].

Measurement of hCG remains today central for diagnosis, treatment and follow-up of gestational trophoblastic diseases (GTD). In order to evaluate this contribution, we conducted a prospective cohort study in the Service of high-risk pregnancy of Rabat Maternity Les Orangers and the Laboratory of Rabat Military Teaching Hospital Mohammed V over a period of eighteen months. 35 patients were included.