Hepatoprotective efficacy of Argemone mexicana L. root in paracetamol-induced hepatotoxicity in a rat model.

Ethnopharmacological Relevance: Argemone mexicana L. (Papaveraceae), a weed that thrives in the tropical and subtropical areas of South and Central America, Mexico, Caribbean Islands and India. In India, it has been used traditionally to treat vesicular calculus, inflammatory conditions, and hepatobiliary disorders.

Taxonomic review of the genus Lemyra Walker (Erebidae: Arctiinae) from India.

In the present manuscript, we review the genus Lemyra Walker, 1856 from India by examining the specimens collected freshly from different parts of India from 2016 to 2019 and from the National Zoological Collection of the Zoological Survey of India (NZCZSI). The revised status of Lemyra in India is presented by describing seven new species: Lemyra (Thyrgorina) rubripecta sp. nov.

Protective effect of Tecoma stans (L.) Juss.ex Kunth in CFA-induced arthritic rats.

Ethnopharmacological Relevance: Tecoma stans (L.) Juss.ex Kunth (Bignoniaceae) is mainly found in tropical and subtropical regions of Africa and Asia.

A review of the genus Plutodes Guene (Geometridae: Ennominae) from India with description of one new species.

In the present paper, we discuss the taxonomy of 11 species of Plutodes Guene, [1858], collected from different regions of India, including description of one new species, P. quadratus sp. nov.

Exploring Piezo1, Piezo2, and TMEM150C in human brain tissues and their correlation with brain biomechanical characteristics.

Unraveling the intricate relationship between mechanical factors and brain activity is a pivotal endeavor, yet the underlying mechanistic model of signaling pathways in brain mechanotransduction remains enigmatic. To bridge this gap, we introduced an in situ multi-scale platform, through which we delineate comprehensive brain biomechanical traits in white matter (WM), grey-white matter junctions (GW junction), and the pons across human brain tissue from four distinct donors. We investigate the three-dimensional expression patterns of Piezo1, Piezo2, and TMEM150C, while also examining their associated histological features and mechanotransduction signaling networks, particularly focusing on the YAP/β-catenin axis.

Repurposing of clinically proven bioactive compounds for targeted treatment of Alzheimer's disease using molecular docking approach.

Neurodegenerative diseases like Alzheimer's have become a growing concern as it is difficult to cure. Tau protein is found to be playing a major role in Alzheimer's disease, and the majority of drugs that are currently on the market are not only prohibitively expensive but also come packaged with side effects that the body cannot tolerate. Repurposing existing compounds is a successful and optimistic strategy that offers reduced risk and increased possibility.

Application of Diode Laser in Excision of a Peripheral Ameloblastoma - A Case Report.

Rationale: Occurrence of peripheral ameloblastoma (PA) is rare. Excision of PA by diode laser is infrequent.

Patient Concerns: A 27-year-old female patient presented with an asymptomatic mass on the retromolar trigone for the past one year.

Integrative Investigation Reveals the Host-Virus Interactions in Repurposed Drugs Against SARS-CoV-2.

The ongoing COVID-19 outbreak have posed a significant threat to public health worldwide. Recently Toll-like receptor (TLR) has been proposed to be the drug target of SARS-CoV-2 treatment, the specificity and efficacy of such treatments remain unknown. In the present study we performed the investigation of repurposed drugs via a framework comprising of Search Tool for Interacting Chemicals (STITCH), Kyoto Encyclopedia of Genes and Genomes (KEGG), molecular docking, and virus-host-drug interactome mapping.

Contribution to the Erebidae fauna of the Great Nicobar Island, India with description of two new species (Lepidoptera: Noctuoidea).

In the present paper, we describe two new species, Garudinia shompen sp. nov. (Arctiinae) and Plusiodonta nicobarensis sp.

Taxonomy and ecology of genus Psyra Walker, 1860 (Lepidoptera: Geometridae: Ennominae) from Indian Himalaya.

The Psyra Walker, 1860, is a typical Sino-Himalayan genus of the subfamily Ennominae, currently known by 18 species/4 subspecies globally and 9 species from India. This study aims to revise the taxonomy and ecology of Indian Psyra by providing a morphology-based diagnostic key, highlighting their altitudinal, habitat and seasonal preferences, and modelling their distribution based on current and future climatic scenarios. Here, we describe a new species, P.

New records of Notodontidae Stephens, 1829 (Lepidoptera: Noctuoidea) from India.

The present study discusses the systematic accounts of ten species of the family Notodontidae recorded here for the first time from India. The species were collected from different parts of Indian Himalaya, the majority being reported from the Dihang-Dibang Biosphere Reserve, Arunachal Pradesh. Among these ten species, we present two new combinations under subfamily Spataliinae, viz.

Interplay of Ferritin Accumulation and Ferroportin Loss in Ageing Brain: Implication for Protein Aggregation in Down Syndrome Dementia, Alzheimer's, and Parkinson's Diseases.

Iron accumulates in the ageing brain and in brains with neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and Down syndrome (DS) dementia. However, the mechanisms of iron deposition and regional selectivity in the brain are ill-understood. The identification of several proteins that are involved in iron homeostasis, transport, and regulation suggests avenues to explore their function in neurodegenerative diseases.

Taxonomy and ecology of genus Phlogophora Treitschke, 1825 (Lepidoptera: Noctuidae) in Indian Himalaya with description of a new species.

The Genus Phlogophora Treitschke, 1825 (Noctuidae: Xyleninae), widely distributed in Palaearctic and Oriental realms, is especially diverse within Indian Himalaya with 12 known species till now. Current communication reports three species new to India viz. P.

A new species in the genus Chadisra Walker (Notodontidae: Periergosinae) from the Great Nicobar Island, India.

A new species, Chadisra curvipenis N. Singh, Ahmad Raha, sp. nov.

SyNC, a Computationally Extensive and Realistic Neural Net to Identify Relative Impacts of Synaptopathy Mechanisms on Glutamatergic Neurons and Their Networks in Autism and Complex Neurological Disorders.

Synaptic function and experience-dependent plasticity across multiple synapses are dependent on the types of neurons interacting as well as the intricate mechanisms that operate at the molecular level of the synapse. To understand the complexity of information processing at synaptic networks will rely in part on effective computational models. Such models should also evaluate disruptions to synaptic function by multiple mechanisms.

"Gigantic aggressive angiomyxoma" of the jaws: A rare case report.

Angiomyxomas are a group of rare myxoid benign mesenchymal tumors prone to local recurrences. Two types of angiomyxomas are well recognized in the literature: superficial and aggressive angiomyxoma. Aggressive angiomyxomas are relatively uncommon, poorly circumscribed, locally infiltrative myofibroblastic tumors with a specific predilection for the perineal regions and exceedingly rare in the head and neck region.

Typhoid and Enteric Fevers in Intensive Care Unit.

Enteric fever (typhoid and paratyphoid)is caused by and . It is spread by fecal-oral route, largely through contamination of water and foodstuff. Developing countries are the worst affected.

Intraoral Management of Latrogenic Tooth Displacement: A Report of Two Cases and a Brief Review of Literature.

Iatrogenic displacement of a tooth or tooth fragment is a rare but well-recognized complication that occurs during exodontia. The most common sites of dislodgment of a mandibular third molar fragment are the sublingual, submandibular, and pterygomandibular and lateral pharyngeal spaces. Removal of a displaced tooth from these spaces may be complex due to poor visualization and limited access.

Impaired Iron Homeostasis and Haematopoiesis Impacts Inflammation in the Ageing Process in Down Syndrome Dementia.

Down syndrome (DS) subjects are more likely to develop the clinical features of Alzheimer's disease (AD) very early in the disease process due to the additional impact of neuroinflammation and because of activation of innate immunity. Many factors involved in the neuropathology of AD in DS, including epigenetic factors, innate immunity and impaired haematopoiesis, contribute significantly towards the pathophysiology and the enhanced ageing processes seen in DS and as a consequence of the triplication of genes , and , together with the influence of proteins that collectively protect from cellular defects and inflammation, which include hepcidin, ferritin, IL-6 and TREM2. This study is aimed at determining whether genetic variants and inflammatory proteins are involved in haematopoiesis and cellular processes in DS compared with age-matched control participants, particularly with respect to neuroinflammation and accelerated ageing.

Hepcidin Increases Cytokines in Alzheimer's Disease and Down's Syndrome Dementia: Implication of Impaired Iron Homeostasis in Neuroinflammation.

The liver-derived hormone hepcidin, a member of the defensin family of antimicrobial peptides, plays an important role in host defense and innate immunity due to its broad antibacterial and antiviral properties. Ferritin, an iron storage protein is often associated with iron deficiency, hypoferritinemia, hypoxia, and immune complications, which are all significant concerns for systemic infection in Alzheimer's disease (AD) and Down's syndrome (DS) dementia. Serum and post-mortem brain samples were collected from AD, DS and age-matched control subjects.

The migration of metastatic breast cancer cells is regulated by matrix stiffness via YAP signalling.

Matrix stiffness is a driver of breast cancer progression and mechanosensitive transcriptional activator YAP plays an important role in this process. However, the interplay between breast cancer and matrix stiffness, and the significance of this interplay remained largely unknown. Here, we showed an increase in YAP nuclear localization and a higher proliferation rate in both highly metastatic MDA-MB-231 cells and the non-metastatic counterpart MCF-7 cells when they were exposed to the stiff matrix.

Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology.

Objective: In some individuals, coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection leads to a variety of serious inflammatory symptoms, including blood clotting and acute respiratory distress. Death due to COVID-19 shows a steep rise in relation to age. Comorbidities such as type 2 diabetes mellitus (T2DM), hypertension, and cardiovascular disease also increase susceptibility.

Improvements in heat transfer in thermal desalination operation based on removal of salts using ultrasound pretreatment.

Scaling is a major problem in the thermal desalination operation which is mainly attributed to the deposition of salts on the tube, thereby increasing the resistance to heat transfer. To reduce or prevent the formation of scale on heat transfer surfaces, treating desalination concentrates and precipitating sparingly soluble salts can be a promising method. In the present work, the effect of ultrasound pretreatment to the synthetically prepared sea water as desalination feed has been investigated with an objective of intensifying salt removal process and avoiding scale formation leading to better heat transfer rates.

A new species of Nerice Walker, 1855 and further additions to the catalogue of Indian Notodontidae Stephens, 1829 (Lepidoptera: Noctuoidea) from Himalaya with report of range extensions.

The present work deals with the additional species of Notodontidae recorded from different provinces of Indian Himalaya subsequent to the publication of Catalogue of Indian Notodontidae which provided systematic account of 242 species and 10 subspecies. Current communication comprises: (I) Description of a new species of genus Nerice Walker, 1855, Nerice (Nerice) mishmiensis Mazumder, Raha, Chandra Schintlmeister sp. nov.