Publications by authors named "Ragna M S Haegebaert"
Eur J Pharm Biopharm
March 2022
Article Synopsis
- Colorectal cancer (CRC) makes up about 10% of cancer cases globally, and traditional treatments like chemotherapy and surgery have limited effectiveness for advanced cases.
- Toll-like receptor (TLR) agonists can enhance the immune response against tumors by stimulating key immune cells, but their activation can also lead to negative effects like tumor growth and resistance to treatment.
- There's a need for nanoparticle delivery systems that can effectively target TLR agonists to specific immune cells to improve CRC treatment, and this review will explore the challenges and recent advancements in developing these targeted nanoparticles.
Article Synopsis
- Understanding protein interactions is key for studying complex biomolecular processes and developing new biopharmaceutical therapies.
- Current methods struggle to fully characterize these interactions due to limitations like surface immobilization and inability to mimic real biological conditions.
- This study introduces flow induced dispersion analysis (FIDA) as a solution for in-solution characterization of protein interactions, demonstrating its effectiveness in analyzing the binding mechanism between TNF-α and adalimumab, including complex sizes and binding affinities.
